706759-33-3Relevant academic research and scientific papers
1-Alkyl-4-acylpiperazines as a new class of imidazole-free histamine H 3 receptor antagonists
Zaragoza, Florencio,Stephensen, Henrik,Knudsen, Sanne M.,Pridal, Lone,Wulff, Birgitte S.,Rimvall, Karin
, p. 2833 - 2838 (2004)
With the aim of identifying structurally novel, centrally acting histamine H3 antagonists, arrays of monoacyldiamines were screened. This led to the discovery of a series of 1-alkyl-4-acylpiperazines which were potent antagonists at the human histamine H3 receptor. The most potent amides had antagonist potencies in the subnanomolar range.
