706790-46-7Relevant academic research and scientific papers
Synthesis and NMR structural analysis of 2κ-OMe-Uridin-3′-yl (3′,5′)-5′-O-(N-isobutyryl-2′-OMe-cytidine) methylthiophosphonates
Olejniczak, Sebastian,Potrzebowski, Marek J.,Wozniak, Lucyna A.
, p. 1958 - 1966 (2004)
Detailed analysis of the molecular structures of both the Fasteluted and the Slow-eluted (the notation Slow and Fast corresponds to the relative mobility properties of compounds in silica gel column chromatography under normal phase conditions, see Exp. S
Consequences of P-chirality in chimeric 2′-O- methyloligoribonucleotides with stereoregular methylphosphonothioate linkages
Wozniak, Lucyna A.,Janicka, Magdalena,Bukowiecka-Matusiak, Malgorzata
, p. 5189 - 5197 (2007/10/03)
Stereoregular chimeric oligonucleotides modified with diastereomerically pure methylphosphonothioate linkages interact with complementary DNA or RNA templates in a stereo-dependent manner. There is an unprecedented large difference in the stability of duplexes of oligonucleotides modified with alternating methylphosphonothioate linkages (ΔTm = 34°C) that is dependent only on the stereochemistry of the methylphosphonothioate phosphorus centres. The nature of these interactions was studied by circular dichroism and NMR spectroscopy, and a thermodynamic analysis was performed. The collected data indicate that the absolute configuration at the P-chiral methylphosphonothioate linkages in chimeric 2′-O-methylribonucleotides could, in some cases, determine the global conformation of single-strand oligonucleotides and constrain the conformation of hybrid duplexes formed with RNA. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.
