706791-87-9Relevant articles and documents
Discovery of novel TrkA allosteric inhibitors: Structure-based virtual screening, biological evaluation and preliminary SAR studies
Ding, Ke,Guo, Jing,Lu, Xiaoyun,Wang, Jie,Wang, Zuqin,Xiang, Shuang,Zhang, Zhang,Zhou, Yang
, (2021/12/08)
Tropomyosin receptor kinases A (TrkA) is a potential therapeutic target for the treatment of numerous tumor types and chronic pain. However, most of the reported TrkA inhibitors are ATP competitive pan-Trks inhibitors that lack subtype selectivity. A sele