706818-91-9

Upstream product

• 367946-80-3 methyl 2-fluoro-3,5-dinitrobenzoic ester 

Downstream Products

• 870288-63-4 1,1-dimethylethyl {(3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-oxo-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate 
• 870288-62-3 1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate 
• 870288-61-2 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide 
• 870288-60-1 methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]benzoate 
• 706795-00-8 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]-benzoic acid 
• 706792-62-3 methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-nitrobenzoate 
• 706792-66-7 methyl 5-amino-3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluorobenzoate 
• 706792-60-1 methyl 3-{[(4-chlorobutyl)sulfonyl]amino}-2-fluoro-5-nitrobenzoate 
• 706792-56-5 methyl 3-{bis[(3-chloropropyl)sulfonyl]amino}-2-fluoro-5-nitrobenzoate 
• 706792-57-6 methyl 3-{bis[(4-chlorobutyl)sulfonyl]amino}-2-fluoro-5-nitrobenzoate 

Relevant academic research and scientific papers

BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells

This article is focusing on further optimization of previously described hydroxy ethylamine (HEA) BACE-1 inhibitors obtained from a focused library with the support of X-ray crystallography. Optimization of the non-prime side of our inhibitors and introdu

N, N’-SUBSTITUTED-1,3-DIAMINO-2-OXOPROPANE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND USE

The present invention relates to novel ketone compounds having Asp2 (β-secretase, BACE1 or Memapsin 2) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by ele

HYDROXYETHYLAMINE DERIVATIVES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

The present invention relates to novel hydroxyethylamine compounds of formula (I): (I) having Asp2 (-secretase, BACE1 or Memapsin) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by elevated-amyloid levels or-amyloid deposits, particularly Alzheimer's disease.