870288-63-4

Upstream product

• 367946-80-3 methyl 2-fluoro-3,5-dinitrobenzoic ester 
• 870288-61-2 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-N-[(1S,2R)-2-hydroxy-3-({[3-(methyloxy)phenyl]methyl}amino)-1-(phenylmethyl)propyl]-5-[(1-methylethyl)amino]benzamide 
• 706792-57-6 methyl 3-{bis[(4-chlorobutyl)sulfonyl]amino}-2-fluoro-5-nitrobenzoate 
• 870288-60-1 methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]benzoate 
• 706795-00-8 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]-benzoic acid 
• 706792-62-3 methyl 3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-nitrobenzoate 
• 706792-66-7 methyl 5-amino-3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluorobenzoate 
• 706818-91-9 methyl 3-amino-2-fluoro-5-nitrobenzoate 
• 388072-87-5 [(1S,2R)-1-benzyl-2-hydroxy-3-(3-methoxybenzylamino)propyl]carbamic acid tert-butyl ester 
• 870288-62-3 1,1-dimethylethyl {(2R,3S)-3-[({3-(1,1-dioxidotetrahydro-2H-1,2-thiazin-2-yl)-2-fluoro-5-[(1-methylethyl)amino]phenyl}carbonyl)amino]-2-hydroxy-4-phenylbutyl}{[3-(methyloxy)phenyl]methyl}carbamate 

Relevant academic research and scientific papers

N, N’-SUBSTITUTED-1,3-DIAMINO-2-OXOPROPANE DERIVATIVES, THEIR PHARMACEUTICAL COMPOSITIONS AND USE

The present invention relates to novel ketone compounds having Asp2 (β-secretase, BACE1 or Memapsin 2) inhibitory activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases characterised by ele