70684-85-4

Upstream product

• 124-38-9 carbon dioxide 
• 286961-15-7 benzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-1 (2H)-pyridinecarboxylate 
• 501-53-1 benzyl chloroformate 
• 68947-42-2 Isoguvacine hydrobromide 

Downstream Products

• 76789-28-1 dibenzyl 1,2,3,6-tetrahydropyridine-1,4-dicarboxylate 
• 76789-18-9 (3RS,4SR)-dibenzyl 3,4-epoxypiperidine-1,4-dicarboxylate 
• 76789-17-8 isoguvacine oxide 

Relevant academic research and scientific papers

Carboxylation of Alkenyl Boronic Acids and Alkenyl Boronic Acid Pinacol Esters with CO2 Catalyzed by Cuprous Halide

A cuprous halide catalysed carboxylation of alkenyl boronic acids and alkenyl boronic acid pinacol esters under CO2, affording the corresponding α, β-unsaturated carboxylic acids in good yield, has been developed. The potassium (E)-trifluoro(styryl)borate is also compatible with this reaction. This simple and efficient copper(I) catalytic system showed good functional group tolerance.

Method for preparing alpha, beta-unsaturated carboxylic acid by reacting alkenyl boron compound with carbon dioxide under catalysis of cuprous halide

The invention discloses a method for preparing alpha, beta-unsaturated carboxylic acid through a carboxylation reaction of an alkenyl boron compound and carbon dioxide under the catalysis of cuprous halide. According to the method, carbon dioxide is used as a C1 source, the cuprous halide is adopted for catalysis, and alkoxide serves as alkali to react in an organic solvent, so the method is simple and easy to implement, has a wide substrate application range, converts various alkenyl boron compounds such as alkenyl boric acid, alkenyl borate and borate into corresponding alpha, beta-unsaturated carboxylic acid under mild conditions, and has a very high yield. The obtained product alpha, beta-unsaturated carboxylic acid is an important intermediate for preparing fine chemical products suchas perfumes, insecticides and the like.

GABA agonists and uptake inhibitors designed as agents with irreversible actions

The synthesis of (3RS,4SR)-3,4-epoxypiperidine-4-carboxylic acid (isoguvacine oxide) 15, related to the specific GABA agonist isoguvacine, is described. Furthermore (3RS,4SR)-3,4-epoxypiperidine-3-carboxylic acid (guvacine oxide) 10 and the hydrobromides