707-34-6

Usage

Uses

Used in Pharmaceutical Industry:
1,3,5-Tribromoadamantane is used as a brominated impurity in the production of Memantine (M218000) for its antiparkinsonian and antispasmodic properties. Memantine is a medication that is primarily used to treat Parkinson's disease and various spastic conditions by acting on the central nervous system.
As an impurity in Memantine, 1,3,5-Tribromoadamantane may have potential effects on the overall efficacy and safety of the drug. It is essential to monitor and control the levels of this impurity during the manufacturing process to ensure the quality and effectiveness of Memantine as a pharmaceutical product.

InChI:InChI=1S/C10H13Br3/c11-8-1-7-2-9(12,4-8)6-10(13,3-7)5-8/h7H,1-6H2

Upstream product

• 281-23-2 adamantane 
• 2825-83-4 (3aR,4R,7S,7aS)-octahydro-1H-4,7-methanoindene 

Downstream Products

• 7314-86-5 1,3,5,7-tetrabromoadamantane 

Relevant academic research and scientific papers

Hollow sphere formation from a three-dimensional structure composed of an adamantane-based cage

An adamantane-based cage with a three-dimensional (3D) framework was synthesized by the copper-mediated acetylene coupling reaction, in which two 1,3,5-triethynyladamantane units were linked by phenyldiacetylenic bridges possessing ester groups. X-ray cry

Rational Construction of Borromean Linked Crystalline Organic Polymers

Attributed to the unique topological complexity and elegant beauty, Borromean systems are attracting intense attention. However, at present, the construction of Borromean linked organic polymers remains a challenge. To address this formidable challenge, we developed a supramolecular-synthon-driven approach to fabricate Borromean linked organic polymer. The solvothermal condensation reaction of a judiciously selected trigonal pyramidal building block, 1,3,5-Tris(4-aminophenyl)adamantane, with linear dialdehyde building blocks allowed the construction of two rare covalent organic frameworks (COFs) with high crystallinity and robustness. Structure refinement unveiled the successful formation of entangled 2D→2D Borromean arrayed structures. Both the two COFs were of microporosity and thus demonstrated the potentials for gas separation. The successful synthesis of the first two Borromean linked organic polymers paves the avenue to expand the supramolecular-synthon-driven approach to other building blocks and topologies, and broadens the family and scope of COFs.

A process for the preparation of adamantane triols

The invention provides a preparation method for adamantanetriol. The method is characterized by consisting of two phases: phase one, reacting adamantane with bromine to generate 1, 3, 5-tribromoadamantane; phage 2, under the action of silver sulfate and concentrated sulfuric acid, letting 1, 3, 5-tribromoadamantane generate adamantanetriol. According to the synthesis method provided by the invention, by selecting the reaction conditions of each step, like reaction temperature, reaction ratio, reaction time, reaction feedstock and the like, the problems of difficult purification, low reaction yield, low product purity, inapplicability to large-scale industrial production and the like in existing technical disclosures can be overcome.

An adamantane-based building block for DNA networks

DNA governs the storage and transfer of genetic information through generations in all living systems with the exception of some viruses. Its physicochemical nature and the Watson-Crick base pairing properties allow molecular constructions at nanometer le

Synthesis of Well-Defined Tower-Shaped 1,3,5-Trisubstituted Adamantanes Incorporating a Macrocyclic Trilactam Ring System

We describe the synthesis of two novel well-defined tower-shaped 1,3,5-trisubstituted adamantanes 30 and 33 that incorporate a macrocyclic trilactam ring system. Each nanoscale molecule has a broad tripodal base consisting of three identical sulfur-contai

Face selection in the reduction of p,p'-disubstituted 5,7-diphenyl-2- adamantanones and hydrolysis of the corresponding 2-adamantyl tosylates

The reduction of 5,7-diphenyl-2-adamantanone with sodium borohydride in 2- propanol is affected by the introduction of a p-nitro substituent in one of the rings: the E-alcohol is obtained in small but easily measurable excess of 1.30:1. Conversely, the in

CATALYTIC BROMINATION OF ADAMANTANE IN 1,1,2-TRICHLORO-1,2,2-TRIFLUOROETHANE AND PERFLUOROBENZENE

The catalytic bromination of adamantane with bromine in 1,1,2-trifluoro-1,2,2-trifluoroethane (Freon 113) or perfluorobenzene in the presence of iron leads to 1,3-dibromoadamantane.In the presence of aluminum chloride in 1,1,2-trichloro-1,2,2-trifluoroethane a complex mixture of polychlorobromoadamantanes is formed on account of the chlorination of the adamantane by the solvent.