7071-14-9Relevant academic research and scientific papers
A facile synthesis of formazan dyes conjugated with plasmonic nanoparticles as photosensitizers in photodynamic therapy against leukemia cell line
Khalifa, Mohamed E.,Elkhawass, Elham A.,Pardede, Antoni,Ninomiya, Masayuki,Tanaka, Kaori,Koketsu, Mamoru
, p. 2195 - 2206 (2018/11/10)
Abstract: A series of 1,5-bis(4-aryl/heteryl)-3-cyanoformazan derivatives was synthesized and characterized by spectral analysis. The synthesis strategy involved an easy and practical diazo coupling of different aryl (heteryl) diazonium salts with cyanoacetic acid. The synthesized compounds were electrostatically conjugated to gold and/or silver nanoparticles in dimethylsulfoxide and were examined as photosensitizers for photodynamic therapy (PDT). The PDT activity of the formazan derivatives alone and conjugated with metal nanoparticles was investigated against HL-60 cells under dark and light conditions. Formazan derivatives and their conjugates showed variable promising anticancer activity in dark and light conditions related to their structures. The interaction of synthesized formazan derivatives with metal nanoparticles enhanced the light absorption of the dyes and thus showed remarkable increase in PDT against cancer cells. Graphical abstract: [Figure not available: see fulltext.].
Microwave-Assisted Synthesis of Arylazoaminopyrazoles as Disperse Dyes for Textile Printing
Khattab, Tawfik A.,Haggag, Karima M.,Elnagdi, Mohamed H.,Abdelrahman, Amal A.,Abdelmoez Aly, Sherif
, p. 766 - 772 (2016/07/11)
The synthesis of heterocyclic azo-dyes via conventional heating and microwave (MW) heating was investigated. From a sequence of reactions starting from cyanoacetic acid, 4-arylazo-2H-pyrazol-3-ylamines and 4-arylazo-2-phenyl-2H-pyrazol-3-ylamines were obtained. The structures these compounds were obtained by inspection of spectroscopic and analytical techniques including1H and13C NMR spectroscopy, IR spectroscopy, mass spectrometry, and elemental analysis. The fastness properties and UV/Vis absorption spectroscopic data of these disperse dyes in printing polyester fabrics were investigated.
