70711-36-3Relevant academic research and scientific papers
A new and simple synthesis of sulfonyl ureas from sulfonamides and N-alkyl-1,2,4-dithiazolidine-3,5-diones
Gessner, Richard K.,Chibale, Kelly
experimental part, p. 2839 - 2843 (2010/03/03)
A new, short, and simple synthetic approach to sulfonyl ureas is reported. The method involves the transformation of readily synthesized N-alkyl-1,2,4-dithiazolidine-3,5-diones by reaction with primary sulfonamides. Sulfonyl ureas were obtained in moderat
Synthetic and structural studies on 1,2,4-dithiazolidine-3,5-dione derivatives
Wood, Mark E.,Cane-Honeysett, Daniel J.,Dowle, Michael D.,Coles, Simon J.,Hursthouse, Michael B.
, p. 3015 - 3023 (2007/10/03)
Methods have been developed for the N-alkylation of 1,2,4-dithiazolidine-3,5-dione 2 and the subsequent conversion of the N-alkylated derivatives into isocyanates 5. An extension of this methodology onto a solid-support is also reported. X-ray crystallographic analysis has been carried out on potassium 1,2,4-dithiazolidine-3,5-dione 3 for structural comparison with the parent heterocycle 2.
1,2,4-Dithiazolidine-3,5-dione: A nucleophilic isocyanate 'building block'
Cane-Honeysett,Dowle,Wood
, p. 1622 - 1624 (2007/10/03)
Mild conditions are described for the direct N-alkylation of 1,2,4-dithiazolidine-3,5-dione 1 using a variety of alkyl halides with subsequent conversion of the products 2 into alkyl isocyanates using triphenylphosphine.
