70720-85-3Relevant academic research and scientific papers
Nickel-catalyzed coupling of fluoroarenes and amines
Zhu, Feng,Wang, Zhong-Xia
, p. 3694 - 3702 (2013)
The combination of bis(cyclooctadiene)nickel [Ni(COD)2] and 1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene hydrochloride (IPr×HCl) effectively catalyzes coupling of fluoroarenes with amines in the presence of sodium tert-butoxide (t-BuONa). A
Toluene and its Derivatives as Atom-Efficient Benzylating Agents for Secondary Amines
Sch?nbauer, David,Lukas, Florian,Schnürch, Michael
, p. 94 - 98 (2019/01/04)
Toluene as a replacement for common N -benzylating agents, such as benzyl bromide, can be an atom-efficient alternative reagent. Under nickel catalysis and mildly oxidative conditions, it is possible to activate toluene efficiently and use it directly for the benzylation of different 2-aminopyridines. The transformation is not restricted to simple toluene, but also substituted derivatives give the desired product in good yields. Effective cleavage of the pyridine moiety is presented.
Amination of Phosphorodiamidate-Substituted Pyridines and Related N-Heterocycles with Magnesium Amides
Balkenhohl, Moritz,Heinz, Benjamin,Abegg, Thomas,Knochel, Paul
supporting information, p. 8057 - 8060 (2019/01/14)
The amination of various phosphorodiamidate-substituted pyridines, quinolines, and quinoxaline with magnesium amides R2NMgCl·LiCl proceeds at room temperature within 8 h. Several pharmaceutically active amines were suitable substrates for this amination procedure, and also the antihistaminic tripelennamine was prepared. Additionally, several heterocyclic phosphorodiamidates underwent directed ortho-metalation (DoM) using TMPMgCl·LiCl (TMP = 2,2,6,6-tetramethylpiperidyl) or TMP2Mg·2LiCl, followed by electrophilic functionalization prior to the amination step, which led to ortho-functionalized aminated N-heterocycles.
