70726-17-9

Upstream product

• 100-02-7 4-nitro-phenol 
• 2973-19-5 2-hydroxy-5-nitrobenzyl chloride 
• 603-35-0 triphenylphosphine 

Downstream Products

• 141627-42-1 (2-butyl-5-nitrobenzofuran-3-yl)(4-methoxyphenyl)methanone 
• 141645-16-1 2-n-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran 
• 133238-87-6 2-(n-butyl)-5-nitrobenzofuran 
• 23136-39-2 2-acetyl-5-nitrobenzofuran 
• 101315-49-5 (5-nitrobenzofuran-2-yl)(phenyl)methanone 

Relevant academic research and scientific papers

Preparation method of key intermediate of dronedarone

The invention relates to a preparation method of a key intermediate of drug dronedarone for treating atrial fibrillation, and specifically relates to the 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran. According to the method provided by the invention, a series of reactions are performed by using inexpensive p-nitrophenol as a starting material to prepare the 2-butyl-3-(4-hydroxybenzoyl)-5-nitrobenzofuran, the process is smooth, the costs are lower, the yield is higher, the controllability is stronger, and the method is suitable for industrial production.

New Syntheses of 2-Acylbenzofurans, 2-Acylindoles, 2-Indolylcarboxylates, and 2-Quinolones by Intramolecular Wittig Reaction

The title compounds are obtained by intramolecular Wittiig reaction of 2-(α-ketoacyloxy)-, 2-(α-ketoacylamino)-, or 2-benzyltriphenylphosphonium salts, respectively.