70736-27-5

Upstream product

• 4755-81-1 methyl 2-chloroacetoacetate 
• 4346-59-2 para-methoxyphenyldiazonium chloride 
• 104-94-9 4-methoxy-aniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 55667-43-1 1,1-dichloro-4-methyl-penta-1,3-diene 
• 1265897-67-3 3,3a,4,5,6,7,7a-hepta(methoxycarbonyl)-1-(4-methoxyphenyl)-3a,7a-dihydroindazole 
• 79-01-6 Trichloroethylene 

Downstream Products

• 96722-66-6 1-(4-Methoxy-phenyl)-5-phenyl-1H-pyrazole-3,4-dicarboxylic acid 4-ethyl ester 3-methyl ester 
• 54624-72-5 dimethyl 1-(4-methoxyphenyl)-1H-pyrazole-3,4-dicarboxylate 
• 218632-23-6 Dimethyl 1-[(4-methoxy)phenyl]pyrazole-3,5-dicarboxylate 
• 1196967-10-8 C₁₉H₁₇N₃O₄ 
• 1196967-11-9 C₁₉H₁₇N₃O₄ 
• 1196966-98-9 C₂₀H₁₈N₂O₅ 
• 1196966-99-0 C₂₀H₁₈N₂O₅ 
• 1260001-57-7 methyl 4-formyl-1-(4-methoxyphenyl)-5-[(2-phenyl-1,3-dioxolan-2-yl)-methylthio]-1H-pyrazole-3-carboxylate 
• 1260001-48-6 methyl 1-(4-methoxyphenyl)-5-(phenylthio)-1H-pyrazole-3-carboxylate 
• 1260001-37-3 methyl 1-(4-methoxyphenyl)-5-(phenylsulfonyl)-1H-pyrazole-3-carboxylate 
• 1260001-43-1 methyl 1-(4-methoxyphenyl)-4-(phenylsulfonyl)-1H-pyrazole-3-carboxylate 
• 1260001-51-1 4-ethyl 3-methyl 1-(4-methoxyphenyl)-5-(phenylthio)-1H-pyrazole-3,4-dicarboxylate 
• 1260001-40-8 4-ethyl 3-methyl 1-(4-methoxyphenyl)-5-(phenylsulfonyl)-1H-pyrazole-3,4-dicarboxylate 
• 1260001-46-4 5-ethyl 3-methyl 1-(4-methoxyphenyl)-4-(phenylsulfonyl)-1H-pyrazole-3,5-dicarboxylate 

Relevant academic research and scientific papers

HYDRAZINE COMPOUND AS BLOOD COAGULATION FACTOR Xa INHIBITOR

Provided is a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein X is selected from a 3-9 membered carbon ring or its phenyl ring, and a 4-10 membered heterocyclic ring or its benzo ring; Y and Z are independently selected from 4-9 membered saturated heterocyclic rings respectively; RI-3 are independently selected from H, F, Cl, Br, I, CN, OH, SH,NH2, CHO, COOH respectively, or selected from C1-10 alkyls or heteroalkyls optionally substituted by R01, C3-10 alkyls ring hydrocarbon groups or heterocyclic hydrocarbon groups, C1-10 alkyls or heteroalkyls substituted by C3-10 ring hydrocarbon groups or heterocyclic hydrocarbon group. The compound can be used as an anticoagulant for treating and preventing thrombotic disorders, and can meet the real needs of selectivity and a potent inhibitor for coagulation Xa.

Generation of 1-aryl-3-methoxycarbonylnitrilimines and their reaction with halogen-containing unsaturated compounds

Thermal decomposition of 1-(4-methoxyphenyl)- and 1-(4-fluorophenyl) hepta(methoxycarbonyl)-3a,7a-dihydroindazoles at 135 C in the presence of allyl or propargyl halides leads to the elimination of hexamethyl benzenehexacarboxylate and the formation of the corresponding pyrazolines or pyrazoles as the products of 1,3-dipolar cycloaddition of 1-aryl-3- methoxycarbonylnitrilimines to the multiple bonds of the substrates used. In the case of vinyl halides, the products of the target reactions are either obtained in low yields or nonexistent, with a side conversions taking place instead. Thus, for example, in the case of 1,1-dichloro-4-methylpenta-1,3-diene, besides hexamethyl benzenehexacarboxylate, 3,5,5-trichloro-2-methylpent-4-en-2-ol and arylchlorohydrazones MeO2CC(Cl)=N-NHAr were unexpectedly isolated as the main products, as well.

1,3-Dipolar cycloaddition of nitrile imines with functionalized acetylenes: Regiocontrolled Sc(OTf)3-catalyzed synthesis of 4- and 5-substituted pyrazoles

1,3-Dipolar cycloaddition of C-aryl-N-aryl- and C-carboxymethyl-N-aryl- nitrile imines with functionalized acetylenes have been studied. Regioisomeric mixtures have been obtained with the 5-substituted pyrazole as the major cycloadduct. Under scandium triflate catalysis a reversal in the regiochemistry was observed, especially in the case of C-carboxymethyl-N-aryl-nitrile imines. Georg Thieme Verlag Stuttgart.

Dipolarophilic behaviour of (arylsulfonyl)allenes towards nitrilimines

The dipolarophilic behaviour of 1-[2-(acetylamino)phenylsulfonyl]propa-1,2-diene 1 towards a series of nitrilimines is here described. Mechanistic possibilities for the formation of pyrazolic products 4-7 are discussed. The Royal Society of Chemistry 2000

HETEROCYCLES FROM NITRILE IMINES. PART I. 1,2,3,4-TETRAHYDRO-1,2,4,5-TETRAZINES

The interaction between ketohydrazones and nitrile imines provides a new and direct synthetic route to 1,2,3,4-tetrahydro-1,2,4,5-tetrazines.Elemental analysis and spectral data are consistent with the assigned tetrazine ring system.