70748-53-7

Usage

InChI:InChI=1/C8H8O3/c9-7-3-1-2-4(5(2)7)6(3)8(10)11/h2-6H,1H2,(H,10,11)

Upstream product

• 50703-31-6 3-hydroxymethyltricyclo<2,2,1,0^2,6>heptan-5-ol diformate 
• 70748-53-7 anti-3-oxotricyclo[2.2.1.0(2,6)]heptane-7-carboxylic acid 
• 50-00-0 formaldehyd 
• 121-46-0 bicyclo[2.2.1]hepta-2,5-diene 
• 50703-32-7 anti-5-carboxytricyclo<2.2.1.0^2,6>heptan-3-one 
• 121-46-0 bicyclo[2.2.1]hepta-2,5-diene 
• 15573-45-2 (1S,2S,3S,6R,7S,9S)-2-Iodo-5-oxo-4-oxa-tricyclo[4.2.1.0^3,7]nonane-9-carboxylic acid 
• 6169-95-5 C₈H₈O₂ 

Downstream Products

• 70659-80-2 5-Oxo-tricyclo[2.2.1.0^2,6]heptane-3-carboxylic acid benzylamide 
• 50703-32-7 (1R,2S,4R,6S,7R)-(+)-3-oxotricyclo<2,2,1,0^2,6>heptane-7-carboxylic acid 
• 50703-32-7 (-)-anti-5-carboxytricyclo<2.2.1.0^2,6>heptan-3-one 
• 50703-32-7 (+)-anti-5-carboxytricyclo<2.2.1.0^2,6>heptan-3-one 
• 50703-32-7 (+)-anti-5-oxotricyclo<2.2.1.0^2,6>heptane-3-carboxylic acid 
• 180324-27-0 (-)-5-oxotricyclo [2,2,1,0^2,6]heptane-3-carboxylic acid 

Relevant academic research and scientific papers

The optically pure sodium alcoholate dextrorotary chlorine forefront of the method for the preparation of

The invention relates to a preparation method of optically pure dextro cloprostenol sodium. The method comprises the following steps: using the combination of ketonic acid and S-phenylethylamine resolving agent, and carrying out chiral resolution to obtain S-propenylphosphonate with the structural formula of R-ketonic acid; then separating to obtain R-chlorone and preparing to obtain R-cloprostenol sodium. The preparation method has the benefits that the optically pure dextro cloprostenol sodium in the invention is called D-cloprostenol sodium for short, the using amount only needs one third of cloprostenol sodium being a racemic modification in current market, and the pesticide effect is obviously better than cloprostenol sodium with three times of using amount.

ABSOLUTE CONFIGURATION OF (1R,2S,4R,6S,7R)-(+)-3-OXOTRICYCLO2,6>HEPTANE-7-CARBOXYLIC ACID

The title acid was assigned absolute configuration on the basis of stereoselective condensation with optically active amines.

Fluoroprostaglandins: Synthesis and Biological Evaluation of the Methyl Esters of (+)-12-Fluoro-, (-)-ent-12-Fluoro-, (+)-15-epi-Fluoro-, and (-)-ent-15-epi-12-Fluoroprostaglandin F2α

The synthesis and biological activity of the methyl esters of (+)-12-fluoroPGF2α, (+)-15-epi-12-fluoroPGF2α, (-)-ent-12-fluoroPGF2α, and (-)-15-epi-12-fluoroPGF2α are described.Each fluoroprostaglandin has been evaluated from pregnancy interruption in the hamster and smooth-muscle stimulating effects on gerbil colon and hamster uterine strips.All fluoroprostaglandins synthesized were shown to be neither substrates for 15-hydroxyprostaglandin dehydrogenase nor inhibitors of the enzyme.

An alternative synthesis of the Corey prostaglandin aldehyde.

This is a detailed description of 1 route to the chemical synthesis of PGs (prostaglandins) and their analogs in the laboratory. The chemical formula and chemical structure of each step in the chain is diagrammed. The aldehyde had served as intermediary in the synthesizing process in previous experiments. In this series of steps, the starting stage was the Prins reaction of norbornadiene and paraform-aldehyde in formic acid. Lactones were used as starting materials in the synthesis. Hydrolysis and oxidation were used to change 1 substance in the process into the next.