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3-(4-chlorophenyl)-6-(3,5-dimethyl-1H-pyrazol-1-yl)pyridazine is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

70751-07-4

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70751-07-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 70751-07-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,0,7,5 and 1 respectively; the second part has 2 digits, 0 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 70751-07:
(7*7)+(6*0)+(5*7)+(4*5)+(3*1)+(2*0)+(1*7)=114
114 % 10 = 4
So 70751-07-4 is a valid CAS Registry Number.

70751-07-4Downstream Products

70751-07-4Relevant academic research and scientific papers

Synthesis, vasorelaxant activity and 2D-QSAR study of some novel pyridazine derivatives

George, Riham F.,Saleh, Dalia O.

, p. 663 - 673 (2016)

Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.

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