European Journal of Medicinal Chemistry p. 663 - 673 (2016)
Update date:2022-08-03
Topics:
George, Riham F.
Saleh, Dalia O.
Novel 3,6-disubstituted pyridazines were synthesized by facile method and screened for their vasorelaxant properties utilizing isolated thoracic rat aortic rings. Compounds 8a and 11a exerted potent vasorelaxant activity (IC50 = 198 and 177 μM, respectively) relative to doxazosin mesylate (used reference standard, IC50 = 226 μM), that, they may represent promising hits for treatment of cardiovascular disorders. The observed activity was validated by a statistically significant QSAR model (N = 32, n = 6, R2 = 0.811782, R2cvOO = 0.7153, R2cvMO = 0.7209, F = 17.9708, s2 = 9.65226 × 10-8) that was obtained employing CODESSA-Pro software.
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Doi:10.1016/S0008-6215(00)85479-8
(1979)Doi:10.1039/jr9480000164
(1948)Doi:10.1016/j.tet.2004.03.020
(2004)Doi:10.1039/b316146c
(2004)Doi:10.1016/0040-4020(79)88026-6
(1979)Doi:10.1002/anie.199711871
(1997)