70757-64-1

Usage

Uses

Used in Pharmaceutical Industry:
2-[4-(1-Methyl-1-phenylethyl)phenoxy]acetohydrazide is used as a building block in the synthesis of pharmaceuticals for its potential antitumor and antibacterial properties, contributing to the development of new drugs with enhanced therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical field, 2-[4-(1-Methyl-1-phenylethyl)phenoxy]acetohydrazide is employed as a key component in the creation of pesticides and other agrochemicals, leveraging its biological activities to protect crops and enhance agricultural productivity.
Used in Chemical Research:
2-[4-(1-Methyl-1-phenylethyl)phenoxy]acetohydrazide serves as an important compound in chemical research, facilitating the exploration of new chemical reactions and the discovery of novel synthetic pathways, which can lead to the creation of advanced materials and compounds with various applications.

InChI:InChI=1/C17H20N2O2/c1-17(2,13-6-4-3-5-7-13)14-8-10-15(11-9-14)21-12-16(20)19-18/h3-11H,12,18H2,1-2H3,(H,19,20)

Upstream product

• 599-64-4 p-cumylphenol 
• 70757-63-0 ethyl 2-(4-(2-phenylpropan-2-yl)phenoxy)acetate 
• 105-39-5 chloroacetic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and larvicidal activity of 1,3,4-oxadiazole derivatives containing a 3-chloropyridin-2-yl-1H-pyrazole scaffold

Abstract: A new series of 1,3,4-oxadiazole derivatives with a 3-chloropyridin-2-yl-1H-pyrazole moiety was designed, synthesized, and characterized. The results of bioassay against Helicoverpa armigera and Plutella xylostella indicated that some of the synthesized compounds showed remarkable larvicidal activity. In particular, the LC50 values of the most active compounds against P. xylostella were 46.5, 23.9, and 13.9?mg/dm3, and against Helicoverpa armigera were 88.3 and 69.5?mg/dm3, the latter being slightly better than commercial chlorpyrifos (LC50 103.77?mg/dm3). Preliminary SAR was also discussed. Graphical abstract: [Figure not available: see fulltext.].

Tirfluoromethylpyridine oxadiazoles (ether)derivative and application thereof

The invention discloses an application of a tirfluoromethylpyridine oxadiazole (ether)derivative in a pesticide. A structure is shown as a general formula I, a compound shown in the general formula Ihas good insecticidal activity, and can be used for controlling insects such as diamondback moth and armyworm. The compound has excellent control effect for insects such as diamondback moth and armyworm, and also has control effect for the insects having resistance to the traditional pesticides, in addition, introduction of fluorine-containing groups such as tirfluoromethylpyridine and oxadiazoleas well as heterocyclic ring can enhance a rate for forming hydrogen bond effect between a compound and a target, and the activity of the compound is increased.

Synthesis, Nematicidal Activity, and 3D-QSAR of Novel 1,3,4-Oxadiazole/ Thiadiazole Thioether Derivatives

Forty one novel 1,3,4-oxadiazole/thiadiazole thioether derivatives containing phenoxy moiety were designed and synthesized. Bioassay demonstrated that some of them showed remarkable activities against Tylenchulus semipenetrans in vitro and in vivo. Compounds 20, 21, 35 and 39 showed excellent lethal activities after treatment for 48?h in vitro, with LC50 values of 13.4?±?1.8, 11.7?±?2.5, 13.7?±?2.4 and 13.3?±?1.1?mg·L–1, respectively, which were obviously superior to fosthiazate (49.1?±?2.8?mg·L–1) and avermectin (26.6?±?2.3?mg·L–1). Compound 21 can effectively control the citrus nematode disease caused by T. semipenetrans at 200?mg·L–1 in vivo with (68?±?3)% inhibitory effect, which was even better than that of avermectin ((63?±?2)%). The CoMFA and CoMSIA models of three-dimensional quantitative structure-activity relationships (3D-QSARs) were established. The compound 33 was designed based on the 3D-QSAR models with more vigorous nematicidal activities in vitro (LC50?=?9.8?±?1.4?mg·L–1) and in vivo ((70?±?5)%). These results demonstrated that compound 33 can be considered as a potential nematicide.

2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as preparation method and application thereof

The invention discloses 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives as well as a preparation method and an application thereof. The 2,5-substituent-1,3,4-oxadiazole (thiadiazole) thioether derivatives have the general formula (I) shown in the following specification, wherein R1 represents as 4-chlorphenyl, 4-fluorophenyl, 4-methylphenyl, 4-methoxyphenyl, 4-nitrophenyl, 4-cyano-3,5-difluorophenyl, 4-trifluoromethylphenyl, 4-trifluoromethoxyphenyl, 4-t-butylphenyl, 2-fluorophenyl and other substituents; R2 represents methyl, ethyl, 4-chlorobenzyl, 2,4-dichlorobenzyl, 4-trifluoromethoxy, benzyl, 4-fluorobenzyl, 4-chlorobenzyl and other substituents; X represents O or S. The compound can be used as a pesticide for killing crop nematode and inhibiting bacterial diseases of crops.

Isolation and Utilization of 4-(alpha,alpha-dimethylbenzyl)phenol to Synthesis of Derivatives of Phenoxy-alkanecarbonylic Acid.

A description is given of the method of isolating 4-(alpha,alpha-dimethylbenzyl)phenol from post-phenol tar which is a waste product in the cumene method of producing phenol and acetone. The isolated phenol has been used as the starting material for synthesizing derivatives such as: esters, amides, anilides and hydrazides of 4-(alpha,alpha-dimethylbenzyl)phenoxyacetic, -alpha-propionic and -isobutyric acids.