70779-13-4Relevant academic research and scientific papers
Asymmetric hetero-Diels-Alder reactions with heterocumulenes
Elliott, Mark C.,Monk, Alexandra E.,Kruiswijk, Elbertus,Hibbs, David E.,Jenkins, Robert L.,Jones, David V.
, p. 1379 - 1382 (1999)
Chiral 2-alkenyloxazolines and 2-alkenylthiazolines react with isocyanates and ketenes to give formal hetero-Diels-Alder adducts with complete diastereocontrol. In each case an electron-rich double bond in the adduct is prone to a second addition of the heterocumulene. In the case of the oxazoline adducts the second addition is faster than the first, while with thiazolines the second addition is slower so that a different heterocumulene can be incorporated.
