27565-37-3Relevant academic research and scientific papers
Microwave-Assisted Synthesis of 2-Substituted 2-Thiazolines and 5,6-Dihydro-4 H -1,3-thiazines
Bisceglia, Juan A.,Kilimciler, Natalia B.,Mancinelli, Michele,Mollo, María C.,Orelli, Liliana R.
, p. 1666 - 1679 (2020/06/01)
An efficient and general method for the synthesis of 2-substituted thiazolines and 5,6-dihydro-4 H -1,3-thiazines is developed via microwave-assisted ring closure of ω-thioamidoalcohols promoted by ethyl polyphosphate (PPE). The cyclization reaction involves an S N 2-type mechanism and features the advantages of very short reaction times, high yields and a predictable stereochemical outcome. The acyclic precursors are prepared in high overall yields by an improved diacylation-thionation-saponification sequence from commercially available ω-amino alcohols. The whole process is metal-free and operationally simple.
Diastereoselective dimerisation of alkenylthiazolines: A combined synthetic and computational study
Beutler, Ariane,Davies, Christopher D.,Elliott, Mark C.,Galea, Natasha M.,Long, Matthew S.,Willock, David J.,Wood, John L.
, p. 3791 - 3800 (2007/10/03)
The acylative dimerisation of 2-alkenyl-1,3-thiazolines 1 gives compounds 3 and 8 upon treatment with trichloroacetyl chloride and trifluoroacetic anhydride, respectively. This reaction is completely diastereoselective, in particular giving only a single
Facile Syntheses of Oxazolines and Thiazolines with N-Acylbenzotriazoles under Microwave Irradiation
Katritzky, Alan R.,Cai, Chunming,Suzuki, Kazuyuki,Singh, Sandeep K.
, p. 811 - 814 (2007/10/03)
Microwave reactions of 2-amino-2-methyl-1-propanol (2) or 2-aminoethanethiol hydrochloride (4) with readily available N-acylbenzotriazoles 1a-j in the presence of SOCl2 produced 2-substituted 2-oxazolines 3a-j in 84-98% yields and 2-substituted
A one step synthesis of thiazolines from esters
Busacca, Carl A.,Dong, Yong,Spinelli, Earl M.
, p. 2935 - 2938 (2007/10/03)
Condensation of the triisobutylaluminum complex of cysteamine HCl with a variety of carboxylic esters furnishes thiazolines in one step. This new method has been applied to chiral α-aminoesters to give α-amino thiazolines of high optical purity, yet N-ben
