70783-99-2

Upstream product

• 779-89-5 3-(trifluoromethyl)cinnamic acid 
• 70311-33-0 ethyl 3-(3-trifluoromethylphenyl)-propionate 
• 756-79-6 dimethyl methane phosphonate 
• 585-50-2 3-(3-trifluoromethylphenyl)propanoic acid 
• 294856-02-3 methyl 3-(3-(trifluoromethyl)phenyl)propanoate 

Downstream Products

• 294856-05-6 (3aR,4R,5R,6aS)-5-Hydroxy-4-[(E)-(S)-3-hydroxy-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-2-one 
• 294856-04-5 Benzoic acid (3aR,4R,5R,6aS)-4-[(E)-(S)-3-hydroxy-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 294856-07-8 (Z)-7-{(1R,2R,3R,5S)-5-Hydroxy-3-(tetrahydro-pyran-2-yloxy)-2-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-cyclopentyl}-hept-5-enoic acid 
• 294856-06-7 (3aR,4R,5R,6aS)-5-(Tetrahydro-pyran-2-yloxy)-4-[(E)-(S)-3-(tetrahydro-pyran-2-yloxy)-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-2-one 
• 221246-34-0 17-(3-trifluoromethylphenyl)-17-trinor prostaglandin F_2α 
• 294856-03-4 Benzoic acid (3aR,4R,5R,6aS)-2-oxo-4-[(E)-3-oxo-5-(3-trifluoromethyl-phenyl)-pent-1-enyl]-hexahydro-cyclopenta[b]furan-5-yl ester 

Relevant academic research and scientific papers

Synthesis and in vitro evaluation of human FP-receptor selective prostaglandin analogues

The in vitro evaluation of a series of saturated prostaglandins revealed that compounds with omega chin aromatic rings retain nanomolar potency for the human prostaglandin F receptor (hFP receptor), exemplified by compound 8. In contrast, the double bonds are required for activity in the series with an acyclic omega chain as in PGF(2α). (C) 2000 Published by Elsevier Science Ltd.

Tertiary alcohols

Tertiary alcohols of the formula: STR1 wherein Y1 represents a carbonyl or hydroxymethylene group, and either (i) A1 represents a direct bond and R1 represents a phenyl group which may optionally carry one or more substituents selected from halogen atoms, straight- or branched-chain alkyl or alkoxy groups, each containing from 1 to 4 carbon atoms, and the trifluoromethyl group, or (ii) A1 represents a straight- or branched-chain alkylene group containing from 1 to 10 carbon atoms and R1 represents a hydrogen atom, or a phenyl, phenoxy or phenylthio group each of which may optionally carry one or more substituents selected from halogen atoms, straight- or branched-chain alkyl or alkoxy groups, each containing from 1 to 4 carbon atoms, and the trifluoromethyl group, are new compounds of use in the field of mammalian reproduction and also of use in the control of insects and acarines.