70311-33-0

Basic information

• Product Name: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER
• Synonyms: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER;ethyl 3-(3-(trifluoroMethyl)phenyl)propanoate;Benzenepropanoic acid, 3-(trifluoroMethyl)-, ethyl ester
• CAS NO: 70311-33-0
• Molecular Formula: C₁₂H₁₃F₃O₂
• Molecular Weight: 246.23
• Mol File: 70311-33-0.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 252.125°C at 760 mmHg
• Flash Point: 74.191°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.453
• CAS DataBase Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(70311-33-0)
• EPA Substance Registry System: 3-(3-TRIFLUOROMETHYL-PHENYL)-PROPIONIC ACID ETHYL ESTER(70311-33-0)

Safety Data

• Hazardous Substances Data: 70311-33-0(Hazardous Substances Data)

Usage

General Description

"3-(3-Trifluoromethyl-phenyl)-propionic Acid Ethyl Ester" is a chemical compound that belongs to the category of organic compounds known as phenylpropanoic acids and derivatives which are organic compounds in which a phenyl group is linked to a carbon atom of a propanoic acid group. The structural representation shows an ethyl ester group and a trifluoromethyl group attached to a phenyl group, making it a derivative of propionic acid. It can be used in a variety of chemical reactions and processes due to its specific structure. The presence of the trifluoromethyl group can enhance the chemical and thermal stability of the compound, also, its potential usage could be found in the development of medicines, polymers, and other chemical products.

InChI:InChI=1/C12H13F3O2/c1-2-17-11(16)7-6-9-4-3-5-10(8-9)12(13,14)15/h3-5,8H,2,6-7H2,1H3

Upstream product

• 116577-12-9 (E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate 
• 116577-12-9 ethyl 3-trifluoromethylcinnamate 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 140-88-5 ethyl acrylate 
• 7664-93-9 sulfuric acid 
• 585-50-2 3-(3-trifluoromethylphenyl)propanoic acid 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 779-89-5 3-(trifluoromethyl)cinnamic acid 
• 401-81-0 m-trifluoromethylphenyl iodide 

Downstream Products

• 70311-34-1 5-(3-trifluoromethylbenzyl)-2-thiouracil 
• 54512-95-7 5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione 
• 70311-35-2 5-(3-trifluoromethylbenzyl)-2-methylthio-4-pyrimidone 
• 70311-36-3 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-trifluoromethylbenzyl)-4-pyrimidone dihydrochloride 
• 70783-99-2 dimethyl 4-(3-trifluoromethylphenyl)-2-oxobutylphosphonate 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 1005205-18-4 3-[3-(trifluoromethyl)phenyl]propanohydrazide 
• 113048-69-4 (E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol 

Relevant articles and documents

Base directed palladium catalysed Heck arylation of acrolein diethyl acetal in water

The selective Heck arylation of acrolein diethyl acetal catalysed by [Pd(NH3)4]Cl2 in the presence of RAME-β-CD in water as solvent is described. Depending on the base (i.e. NaOAc or HN(i-Pr)2) good to high selectivity's towards, respectively, the cinnamaldehydes 2 or the 3-arylpropionic esters 1 were achieved. The results support that depending on the base different palladium intermediate complexes are formed. Using NaOAc, {[ArPdX(H2O)2]} complex is preferentially generated giving the cinnamaldehyde 2. On the other hand, in the presence of HN(i-Pr)2, a L-type ligand, [ArPdX(HN(i-Pr) 2(H2O)] or [ArPdX(HN(i-Pr)2(HN(i-Pr) 2)] will be generated leading to the formation of the 3-arylpropionic ester 1. For the last, coordinated amine participates very probably to the formation of the esters through intramolecular syn β-H elimination.

7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS

The compounds of formula (I) are antagonists of the CCR2 receptor Wherein R1-7 and A are as defined in the claims.

CoBr2(Bpy): An efficient catalyst for the direct conjugate addition of aryl halides or triflates onto activated olefins

An efficient cobalt-catalyzed method devoted to the direct conjugate addition of functionalized aryl compounds onto Michael acceptors is described. The CoBr2(2,2′-bipyridine) complex appears to be an extremely suitable catalyst for the activation of a variety of aromatic reagents ranging from halides to triflates functionalized by reactive groups. This procedure allows for the synthesis of compounds resulting from 1,4-addition in good to excellent yields. The versatility of this original process represents a simple alternative to most known methods using organometallic reagents.