70311-33-0

Usage

Uses

Used in Pharmaceutical Industry:
3-(3-Trifluoromethyl-phenyl)-propionic Acid Ethyl Ester is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and enhanced stability contribute to the development of new drugs with improved properties.
Used in Polymer Industry:
3-(3-Trifluoromethyl-phenyl)-propionic Acid Ethyl Ester is used as a monomer or a building block in the synthesis of polymers. Its specific structure and stability can lead to the creation of new polymers with enhanced properties, such as increased strength, durability, or resistance to environmental factors.
Used in Chemical Product Development:
3-(3-Trifluoromethyl-phenyl)-propionic Acid Ethyl Ester is used as a key component in the development of various chemical products. Its versatility in chemical reactions and processes allows for the creation of new compounds with potential applications in different industries, such as agriculture, materials science, or environmental protection.

InChI:InChI=1/C12H13F3O2/c1-2-17-11(16)7-6-9-4-3-5-10(8-9)12(13,14)15/h3-5,8H,2,6-7H2,1H3

Upstream product

• 7664-93-9 sulfuric acid 
• 585-50-2 3-(3-trifluoromethylphenyl)propanoic acid 
• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 3054-95-3 acrylaldehyde diethyl acetal 
• 454-89-7 3-Trifluoromethylbenzaldehyde 
• 779-89-5 3-(trifluoromethyl)cinnamic acid 
• 140-88-5 ethyl acrylate 
• 401-81-0 m-trifluoromethylphenyl iodide 
• 116577-12-9 ethyl 3-trifluoromethylcinnamate 
• 116577-12-9 (E)-ethyl 3-(3-trifluoromethylphenyl)prop-2-enoate 

Downstream Products

• 54512-95-7 5-(3-trifluoromethyl-benzyl)-1H-pyrimidine-2,4-dione 
• 70311-35-2 5-(3-trifluoromethylbenzyl)-2-methylthio-4-pyrimidone 
• 70311-36-3 2-[2-(5-methyl-4-imidazolylmethylthio)ethylamino]-5-(3-trifluoromethylbenzyl)-4-pyrimidone dihydrochloride 
• 70783-99-2 dimethyl 4-(3-trifluoromethylphenyl)-2-oxobutylphosphonate 
• 78573-45-2 3-[3-(trifluoromethyl)phenyl]propan-1-ol 
• 113048-69-4 (E)-3-(3-trifluoromethylphenyl)prop-2-en-1-ol 
• 1005205-18-4 3-[3-(trifluoromethyl)phenyl]propanohydrazide 
• 70311-34-1 5-(3-trifluoromethylbenzyl)-2-thiouracil 

Relevant academic research and scientific papers

Base directed palladium catalysed Heck arylation of acrolein diethyl acetal in water

The selective Heck arylation of acrolein diethyl acetal catalysed by [Pd(NH3)4]Cl2 in the presence of RAME-β-CD in water as solvent is described. Depending on the base (i.e. NaOAc or HN(i-Pr)2) good to high selectivity's towards, respectively, the cinnamaldehydes 2 or the 3-arylpropionic esters 1 were achieved. The results support that depending on the base different palladium intermediate complexes are formed. Using NaOAc, {[ArPdX(H2O)2]} complex is preferentially generated giving the cinnamaldehyde 2. On the other hand, in the presence of HN(i-Pr)2, a L-type ligand, [ArPdX(HN(i-Pr) 2(H2O)] or [ArPdX(HN(i-Pr)2(HN(i-Pr) 2)] will be generated leading to the formation of the 3-arylpropionic ester 1. For the last, coordinated amine participates very probably to the formation of the esters through intramolecular syn β-H elimination.

7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS

The compounds of formula (I) are antagonists of the CCR2 receptor Wherein R1-7 and A are as defined in the claims.

7-HYDROXY-PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS AND THEIR USE AS CCR2 RECEPTOR ANTAGONISTS

The compounds of formula (I) are antagonists of the CCR2 receptor Wherein R1-7 and A are as defined in the claims.

PROCESS FOR PREPARING CINACALCET HYDROCHLORIDE

Processes for preparing cinacalcet are provided.

CoBr2(Bpy): An efficient catalyst for the direct conjugate addition of aryl halides or triflates onto activated olefins

An efficient cobalt-catalyzed method devoted to the direct conjugate addition of functionalized aryl compounds onto Michael acceptors is described. The CoBr2(2,2′-bipyridine) complex appears to be an extremely suitable catalyst for the activation of a variety of aromatic reagents ranging from halides to triflates functionalized by reactive groups. This procedure allows for the synthesis of compounds resulting from 1,4-addition in good to excellent yields. The versatility of this original process represents a simple alternative to most known methods using organometallic reagents.

3-arylpropanoate esters through the palladium-catalyzed reaction of aryl halides with acrolein diethyl acetal

The reaction of aryl halides with acrolein diethyl acetal in the presence of Pd(OAc)2, n-Bu3N, and n-Bu4NCl in DMF at 90°C affords ethyl 3-arylpropanoates. A variety of functional groups are tolerated in the aryl halides, including ether, aldehyde, ketone, ester, nitrile, and nitro groups. ortho-Substituents do not hamper the reaction. 3-Arylpropanoate esters were isolated in good to excellent yields with many neutral, electron-rich and electron-poor aryl iodides and electron-poor aryl bromide. Neutral and electron-rich aryl bromides gave the desired ester in moderate yields.

Inhibition of uridine phosphorylase: Synthesis and structure-activity relationships of aryl-substituted 5-benzyluracils and 1-[(2- hydroxyethoxy)methyl]-5-benzyluracils

A series of 1-[(2-hydroxyethoxy)methyl]-5-benzyluracils were synthesized and tested for inhibition of murine liver uridine phosphorylase (UrdPase). Inhibitors of UrdPase are reported to enhance the chemotherapeutic utility of 5-fluoro-2'-deoxyuridine and 5-fluorouracil and to ameliorate zidovudine- induced anemia in animal models. We prepared a series of 5-aryl-substituted analogues of 5-benzylacyclouridine (BAU), a good inhibitor of UrdPase (IC50 of 0.46 μM), to develop a compound with enhanced potency and improved pharmacokinetics. The first phase of structure-activity relationship studies on a series of 32 aryl-substituted 5-benzyluracils found several 5-(3- alkoxybenzyl) analogues of 5-benzyluracil with enhanced potency. The acyclovir side chain, the (2-hydroxyethoxy)methyl group, was substituted on the more potent aryl-substituted 5-benzyluracils. The two most potent compounds, 10y (3-propoxy) and 10dd (3-sec-butoxy), were inhibitors of UrdPase with IC50s of 0.047 and 0.027 μM, respectively. Six compounds were tested in vivo for effects on steady-state concentrations of circulating uridine in rats. Plasma uridine levels were elevated 3-9-fold by compound levels that ranged from 8 to 50 μM.

PHENYL ALKYLAMINOPYRIMIDONES

The compounds are phenyl alkylaminopyrimidones which are histamine H. sub.2-antagonists. A specific compound of the present invention is 2-[2-[3-(dimethylaminomethyl)benzylthio]ethylamino]-5-(6-methyl-3-pyridylme thyl)-4-pyrimidone.

GUANIDINOTHIAZOLYL DERIVATIVES

The compounds are guanidinothiazolyl derivatives which are histamine H. sub.2-antagonists. A specific compound of the present invention is 2-2-(2-guanidino-4-thiazolylmethylthio)ethylamino!-5-(6-methyl-3-pyridylmethy l)-4-pyrimidone.