70787-32-5Relevant academic research and scientific papers
Syntheses of the tricyclic cores of clozapine, dibenzo[b,f][1,4]thiazepin- 11(10H)-one, and dibenzo[b,f][1,4]oxazepin-11(10H)-one in C-14 labeled form by [14C]carbonylation
Elmore, Charles S.,Dorff, Peter N.,Richard Heys
, p. 787 - 792 (2010)
Clozapine has been demonstrated to bind covalently to proteins as a result of metabolic activation that has been proposed to be a precursor to the serious side effects including death that occur in a small percentage of the population. The covalent modifi
