708-49-6Relevant academic research and scientific papers
Ortho-lithiations reassessed: The advantages of deficiency catalysis in hydrocarbon media
Slocum,Reinscheld, Thomas K.,White, Christopher B.,Timmons, Michael D.,Shelton, Philip A.,Slocum, Matthew G.,Sandlin, Rebecca D.,Holland, Erica G.,Kusmic, Damir,Jennings, John A.,Tekin, Kristen C.,Nguyen, Quang,Bush, Steven J.,Keller, Julia M.,Whitley, Paul E.
, p. 1674 - 1686 (2013/05/08)
Hydrocarbon media based metalation procedures involving "deficiency catalysis" are described for the ortho-lithiation of anisole (A), p-chloroanisole (p-ClA), o-, m-, p-methylanisoles (o-, m-, p-MA), the three dimethoxybenzenes (DMB's), dimethylaniline (DMA), dimethybenzylamine (DMBA), m-methoxydimethylaniline (m-MeODMA), and tetramethyl-p-phenylenediamine (p-TMPDA). These procedures involve certain mechanistic considerations, which must be fine-tuned to maximize the extent of metalation (EoM). Our working hypothesis is that a controlled deoligomerization of the n-BuLi hexamer found in hydrocarbon media will afford a "sweet spot" of deoligomerization such that a maximally efficient metalation medium can be formed. In many cases, a substoichiometric ratio of equivalent TMEDA to n-BuLi is 0.1-0.2:1.0, but certain substrates suffer multiple sites of metalation under these conditions, so different promoted hydrocarbon media systems incorporating measured equivalents of an ether have been formulated. This paper represents the summary of our successful efforts to render ortho-lithiations safer, greener, and more atom-economical by use of hydrocarbon solvent media. EoM's of 11 of the 12 substrates under these atom-economical conditions range from 87 to 97%.
Catalytic enantioselective arylation of glyoxylate with arylsilanes: Practical synthesis of optically active mandelic acid derivatives
Aikawa, Kohsuke,Hioki, Yueta,Mikami, Koichi
supporting information; experimental part, p. 2346 - 2350 (2011/06/26)
Just a little does the trick! The catalytic enantioselective arylation using chiral dicationic palladium complexes provides a reliable and useful access to enantiomerically enriched mandelic-acid derivatives. Significantly low catalyst loading (down to 0.002 mol%) as well as easy catalyst handling are the advantage of this practical method.
Ortho-metalation of p-chloroanisole: A media study
Slocum,Dietzel
, p. 1823 - 1826 (2007/10/03)
As the chlorophenyl group is a pharmacophore, its stability toward metalation conditions in conjunction with the methoxy substituent was assessed. For p-chloroanisole metalation ortho to the methoxy group was achieved in high yield using increments of THF in cyclohexane; numerous other regimes afforded lower yields and a competing benzyne pathway.
