70810-27-4

Basic information

• Product Name: 8-Chloroisoquinoline 2-oxide
• Synonyms: 8-Chloroisoquinoline 2-oxide
• CAS NO: 70810-27-4
• Molecular Weight: 0
• Mol File: 70810-27-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 8-Chloroisoquinoline 2-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Chloroisoquinoline 2-oxide(70810-27-4)
• EPA Substance Registry System: 8-Chloroisoquinoline 2-oxide(70810-27-4)

Safety Data

• Hazardous Substances Data: 70810-27-4(Hazardous Substances Data)

Upstream product

• 34784-07-1 8-chloroisoquinoline 

Relevant articles and documents

Method for preparing sulfone and N-oxygen compound by using green and efficient oxidation system

The invention discloses a method for preparing sulfone and N-oxygen compound by using a green and efficient oxidation system. The method comprises the following steps of: by using a tertiary amine compound or aromatic thioether or fatty thioether compound as a raw material, H2O2 as an oxidant, methanol as a reaction solvent and potassium carbonate as an alkali, introducing sulfuryl fluoride 5O2F2gas as an accelerator; performing stirring at room temperature under a sealed condition for oxidation reaction; and after finishing the reaction, filtering to remove solid potassium carbonate, dryingto remove water, filtering to obtain a crude product, and finally carrying out column chromatography separation to obtain a pure product. Tertiary amine is oxidized into an N-oxygen compound, and thethioether is oxidized into sulfone. According to the method, the sulfuryl fluoride (SO2F2) which is very cheap and easy to obtain is used as the reaction promoter, green and environment-friendly hydrogen peroxide (H2O2) is used as an oxidizing agent, and so that the yield of the reaction is generally high; after the reaction, byproducts are only water and inorganic salts (SO4 and F) whichare easy to remove and free of pollution, and the green and efficient oxidation system can be realized, and therefore, the method is suitable for large-scale industrial production.

Rhodium-Catalyzed Atroposelective Construction of Indoles via C?H Bond Activation

Reported herein is the rhodium(III)-catalyzed C?H activation of anilines bearing an N-isoquinolyl directing group for oxidative [3+2] annulation with four classes of internal alkynes, leading to atroposelective indole synthesis via dynamic kinetic annulation with C-N reductive elimination constituting the stereo-determining step. This reaction proceeds under mild conditions with high regio- and enantioselectivity and functional group compatibility.