708209-58-9Relevant academic research and scientific papers
Ligand tuning in the chromium-salen-mediated asymmetric epoxidation of alkenes
McGarrigle,Murphy,Gilheany
, p. 1343 - 1354 (2007/10/03)
A series of Cr(salen) complexes have been synthesised from 5-substituted-3-bromosalicylaldehydes and trans-1,2-cyclohexanediamine. These have been used to probe the Cr(salen)-mediated asymmetric epoxidation of alkenes. No simple correlation was found between the electronic character of the salen-substituents and the enantioselectivity - multiple oxidation pathways are proposed as a possible explanation. Enantioselectivities of up to 90% have been achieved using a novel, synthetically accessible Cr(salen) complex.
