708253-91-2Relevant academic research and scientific papers
INHIBITORS OF CYCLIN DEPENDNT KINASE 7 (CDK7)
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Paragraph 445, (2018/02/28)
The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases (e.g., cancers (e.g., leukemia, melanoma, multiple myeloma), benign neoplasms, angiogenesis, inflammatory diseases, autoinflammatory diseases, and autoimmune diseases) in a subject. Treatment of a subject with a proliferative disease using a compound or composition of the invention may inhibit the aberrant activity of cyclin-dependent kinase 7 (CDK7), and therefore, induce cellular apoptosis and/or inhibit transcription in the subject.
Design and synthesis of conformationally frozen peptide nucleic acid backbone: Chiral piperidine PNA as a hexitol nucleic acid surrogate
Lonkar, Pallavi S.,Kumar, Vaijayanti A.
, p. 2147 - 2149 (2007/10/03)
The design and facile synthesis of novel chiral piperidine PNA from naturally occurring 4-hydroxy-L-proline is reported. The stereospecific ring-expansion reaction to get six-membered piperidine derivative from 5-membered pyrrolidine derivative is exploit
Piperidinyl peptide nucleic acids: Synthesis and DNA-complementation studies
Lonkar, Pallavi,Kumar, Vaijayanti A.
, p. 1105 - 1108 (2007/10/03)
Synthesis of a new six membered PNA analogue by introducing a methylene bridge between β carbon atom of ethylene diamine and β′ carbon atom of linker to nucleobase.
