154429-40-0

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 114676-48-1 (2S,4R)-1-benzyl-4-hydroxyproline methyl ester 
• 51-35-4 4R-4-hydroxyproline 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 144527-44-6 (2S,4R)-methyl-4-hydroxypyrrolidine-2-carboxylate hydrochloride 
• 100-39-0 benzyl bromide 
• 1499-56-5 (R)-4-hydroxy-L-proline ethyl ester 

Downstream Products

• 154343-02-9 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-hydroxy-methyl-pyrrolidin 
• 161564-09-6 (3R,5R)-1-benzyl-5-[(tert-butyldimethylsilyl)oxy]-piperidin-3-ol 
• 882990-40-1 (3R,5R)-1-benzyl-5-[(tert-butyldimethylsilyl)oxy]-3-trityloxypiperidine 
• 519189-06-1 (3R,5R)-1-benzyl-3,5-di[(tert-butyldimethylsilyl)oxy]-piperidine 
• 708253-90-1 [(3R,5S)-5-azido-1-benzyl-3-piperidyl]oxy-tert-butyl-dimethylsilane 
• 708253-89-8 Methanesulfonic acid (3R,5R)-1-benzyl-5-(tert-butyl-dimethyl-silanyloxy)-piperidin-3-yl ester 
• 708253-91-2 tert-butyl N-[(3S,5R)-1-benzyl-5-[tert-butyl(dimethyl)silyl]oxy-3-piperidyl]carbamate 
• 708253-93-4 [3-(3-benzoyl-5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-5-tert-butoxycarbonylamino-piperidin-1-yl]-acetic acid ethyl ester 
• 156440-98-1 (2S,4R)-N-benzyl-4-(tert-butyldimethylsilyloxy)pyrrolidine-2-carbaldehyde 
• 156441-18-8 (2S,4R)-1-benzyl-4-tert-butyldimethylsilyloxy-2-vinylpyrrolidine 
• 1347702-55-9 ((2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)pyrrolidin-2-yl)diphenylmethanol 
• 1347702-56-0 (2S,4R)-1-benzyl-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine 
• 1347702-57-1 (2S,4R)-4-((tert-butyldimethylsilyl)oxy)-2-(methoxydiphenylmethyl)pyrrolidine 
• 1231764-50-3 C₂₆H₄₁NO₂Si₂ 

Relevant academic research and scientific papers

Palladium-Catalyzed Asymmetric (2+3) Annulation of p-Quinone Methides with Trimethylenemethanes: Enantioselective Synthesis of Functionalized Chiral Spirocyclopentyl p-Dienones

A novel asymmetric catalytic (2+3) annulation of p-quinone methides with CN-substituted trimethylenemethane is described under palladium catalysis, providing an alternative approach for the enantioselective construction of highly functionalized chiral spirocyclopentyl p-dienones. Driven by the significant improvement in the reactivity and enantioselectivity, a novel type of non-C2-symmetric phosphoramidite ligand from the chirality-matched combination of (S)-BINOL and sterically demanding amine derived from l-hydroxyproline is evolved and explored for the protocol presented here.

Substituted pyridine compound and its method and use thereof

The invention relates to a novel substitutive pyridine compound, and a pharmaceutically acceptable salt and a pharmaceutical preparation of the substitutive pyridine compound for regulating the activity of protein kinases and regulating signal responses between cells or in the cells. Meanwhile, the invention further relates to a pharmaceutical composition containing the compound provided by the invention, and a method for treating high proliferative diseases of mammals, especially human with the pharmaceutical composition.

A new organocatalytic concept for asymmetric -alkylation of aldehydes

The organocatalytic asymmetric -alkylation of aldehydes by 1,6-conjugated addition of enamines to p-quinone methides is described. Employing a newly developed class of chiral secondary amine catalysts,-diarylmethine-substituted aldehydes with two contiguo

Polystyrene-supported diarylprolinol ethers as highly efficient organocatalysts for Michael-type reactions

α,α-Diphenylprolinol methyl- and trimethylsilyl ethers anchored onto a polystyrene resin have been prepared by a copper-catalyzed azide-alkyne cycloadditions (CuAAC). The catalytic activity and enantioselectivity displayed by the O-trimethylsilyl derivati

NHC-Catalyzed intramolecular redox amidation for the synthesis of functionalized lactams

A very efficient NHC-catalyzed lactamization reaction is reported. For most cases, the ring expansion reaction proceeds to cleanly furnish five- and six-membered N-Ts and N-Bn lactams, without the need for further purification. Evidence is presented suggesting a dual role for the stoichiometric base: (1) deprotonation of the triazolium precatalyst and (2) activation of the nitrogen leaving group through hydrogen bonding.

Highly enantioselective synthesis of β-amino alcohols: A catalytic version

(Chemical Equation Presented) Highly enantioselective rearrangement of β-amino alcohols was realized by using a catalytic amount of trifluoroacetic anhydride.

Enantioselective diethylzinc addition to aromatic and aliphatic aldehydes using (3R,5R)-dihydroxypiperidine derivatives catalyst

A series of chiral (3R,5R)-dihydroxypiperidine derivatives 3a-f were conveniently prepared from trans-4-hydroxy-l-proline and applied to the catalytic enantioselective addition of diethylzinc to benzaldehyde and heptanal. Among them, 3d was found to show

Unusual diastereoselection in the synthesis of nine-membered ring lactams and conformation-controlled transannular reactions to generate optically active indolizidinones

The aza-Claisen rearrangement of vinylpyrrolidines 1 yielded almost exclusively the trans-3,8-disubstituted nine-membered ring lactams 2 (TBS = tBuMe2Si), independent of whether cis or trans isomers were used as starting materials. The conforma