708261-14-7

Upstream product

• 704-13-2 5-formyl-2-nitrophenol 
• 24424-99-5 di-tert-butyl dicarbonate 
• 80410-57-7 3-methoxy-4-nitrobenzaldehyde 
• 882430-21-9 tert-butyl(3-methoxy-4-nitrobenzyloxy)dimethylsilane 
• 882430-23-1 4-((tert-butyldimethylsilyloxy)methyl)-2-methoxyaniline 
• 80866-88-2 (3-methoxy-4-nitrophenyl)methanol 
• 882430-28-6 tert-butyl 4-((tert-butyldimethylsilyloxy)methyl)-2-methoxyphenylcarbamate 

Downstream Products

• 882430-30-0 (4-aminomethyl-2-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 866005-63-2 (4-isothiocyanatomethyl-2-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 882430-32-2 {4-[(4-tert-butyl-benzyloxythiocarbonylamino)-methyl]-2-methoxy-phenyl}-carbamic acid tert-butyl ester 
• 1612184-59-4 C₂₃H₂₃N₃O₄ 
• 1612184-51-6 (E)-2-(2-(4-amino-3-methoxystyryl)-6-methyl-4H-pyran-4-ylidene)malononitrile 
• 1612184-53-8 tert-butyl 4-formyl-2-methoxyphenylcarbamate 
• 866005-61-0 (4-azidomethyl-2-methoxy-phenyl)-carbamic acid tert-butyl ester 
• 882429-18-7 [4-(4-tert-butyl-benzylthiocarbamoyloxymethyl)-2-methoxy-phenyl]-carbamic acid tert-butyl ester 

Relevant academic research and scientific papers

Probing the Intracellular Dynamics of Nitric Oxide and Hydrogen Sulfide Using an Activatable NIR II Fluorescence Reporter

Understanding the complex interplay among gasotransmitters is of great significance but remains technically challenging. In this study, we present the design and synthesis of a dually responsive BOD-NH-SC reporter for probing the dynamic and alternating existence of NO and H2S in living cells. This designed reporter can repeatedly cycle S-nitrosation and transnitrosation reactions when successively treated with NO and H2S, thus affording the interchange of NIR fluorescence at 645 nm (NO) and NIR II fluorescence at 936 nm (H2S). In light of this unique fluorescence alternation between two colors, we synthesized water-soluble BOD-NH-SC dots to visualize the intracellular dynamics of NO and H2S. These molecular probes thus provide a toolbox to elucidate the interplaying roles of NO and H2S in the complex interaction networks of various signal transduction pathways.

METHODS OF DETECTING MYELIN BASIC PROTEIN

A method and a kit for detecting myelin basic protein are provided. The method comprises administering an agent, which binds to myelin basic protein (MBP), to a subject at risk of or diagnosed with a myelin-associated neuropathy, and determining myelination by detecting the agent resided in the subject. The amount of the agent present in the subject is indicative of a myelin-associated neuropathy. A method of quantifying an amount of MBP present in a tissue sample is also provided, wherein the method comprises contacting the tissue sample with the same agent, detecting the agent present in the tissue sample; and quantifying an amount of the agent present in the tissue sample.

Analysis of structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists

The structure-activity relationships for the 'B-region' of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues have been investigated as TRPV1 receptor antagonists. A docking model of potent antagonist 2 with the sensor region of TRPV1 is proposed.

Analysis of structure-activity relationships for the 'B-region' of N-(3-acyloxy-2-benzylpropyl)-N′-[4-(methylsulfonylamino)benzyl]thiourea analogues as vanilloid receptor antagonists: Discovery of an N-hydroxythiourea analogue with potent analgesic activi

The structural modifications on the B-region of the potent and high affinity vanilloid receptor (VR1) lead ligand N-(3-acyloxy-2-benzylpropyl)- N′-[4-(methylsulfonylamino)benzyl]thiourea were investigated by the replacement of the thiourea with