70853-94-0

Usage

Uses

Used in Pharmaceutical Industry:
2,4-dimethylphenylhydroxylamine serves as a crucial intermediate in the synthesis of various pharmaceuticals. Its role in drug production is pivotal, contributing to the development of new medications and the enhancement of existing ones.
Used in Polymer and Plastics Industry:
In the realm of polymers and plastics, 2,4-dimethylphenylhydroxylamine is utilized as both a stabilizer and an antioxidant. Its inclusion in these materials helps to prevent degradation, thereby extending the lifespan and improving the performance of the final products.

InChI:InChI=1/C8H11NO/c1-6-3-4-8(9-10)7(2)5-6/h3-5,9-10H,1-2H3

Upstream product

• 89-87-2 2,4-dimethylnitrobenzene 

Downstream Products

• 26567-10-2 2,2'-dihydroxy-3,3',5,5'-tetramethylbiphenyl 
• 51770-93-5 4-hydroxy-2,4-dimethyl-2,5-cyclohexadienone 
• 69383-61-5 5-chloro-2,4-dimethylaniline 
• 63133-82-4 2-chloro-4,6-dimethylaniline 
• 38974-06-0 1,3-dimethyl-4-nitrosobenzene 
• 69383-60-4 5-bromo-2,4-dimethylaniline 
• 41825-73-4 2-bromo-4,6-dimethylaniline 
• 99766-50-4 bis-(2,4-dimethyl-phenyl)-diazene-N-oxide 
• 105-67-9 2,4-Xylenol 
• 29418-25-5 bis-(2,4-dimethyl-phenyl)-diazene 
• 622010-85-9 C₁₀H₁₃NO₂ 
• 31058-43-2 1,4-diethoxy-2,5-dimethyl-benzene 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 1198-37-4 2,4-dimethylquinoline 

Relevant academic research and scientific papers

METHOD OF REDUCING AROMATIC NITRO COMPOUNDS

A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.

Synthesis of meta-substituted anilines via copper-catalyzed [1,3]-methoxy rearrangement

meta-Substituted anilines were efficiently synthesized via copper-catalyzed [1,3]-methoxy rearrangement of N-methoxyanilines followed by Michael addition of nucleophiles to the in situ generated ortho-quinol imine. The present reaction exhibits excellent

Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke

The ability of a series of aromatic amines present in tobacco smoke (2-, 3-, and 4-methylaniline, 2,3- and 2,4-dimethylaniline) to bind to DNA has been investigated by reacting N-(acyloxy)arylamines with dG, dG nucleotides, and DNA. The predominant products from reactions with dG and the nucleotides were characterized as N-(deoxyguanosin-8-yl)arylamines by spectroscopic and HPLC methods. HPLC and spectroscopic analyses of the modified DNA indicated the same adducts. Analyses of the 1H and 13C NMR spectra suggested that the adducts containing a methyl substituent ortho to the arylamine nitrogen had a higher percentage of syn conformers. This observation was supported by theoretical simulation studies that indicated substantial percentages of low energy syn conformers, increasing with the substitution pattern in the order para meta ortho ortho,para ortho,meta. The results demonstrate that, although single-ring arylamines are considered weak carcinogens, their electrophilic N-acetoxy derivatives, which are plausible metabolic intermediates, react with DNA to yield covalent adducts structurally identical to those derived from carcinogenic polyarylamines, such as 2- aminofluorene and 4-aminobiphenyl. Furthermore, the conformational perturbation induced in DNA by the formation of the monoarylamine-DNA adducts, especially those with an ortho substituent, may contribute to the biological activities of these compounds.