70853-94-0

Basic information

• Product Name: 2,4-dimethylphenylhydroxylamine
• Synonyms: 2,4-dimethylphenylhydroxylamine
• CAS NO: 70853-94-0
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• Mol File: 70853-94-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 239.8°C at 760 mmHg
• Flash Point: 108.5°C
• Appearance: /
• Density: 1.12g/cm³
• Vapor Pressure: 0.0214mmHg at 25°C
• Refractive Index: 1.609
• CAS DataBase Reference: 2,4-dimethylphenylhydroxylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-dimethylphenylhydroxylamine(70853-94-0)
• EPA Substance Registry System: 2,4-dimethylphenylhydroxylamine(70853-94-0)

Safety Data

• Hazardous Substances Data: 70853-94-0(Hazardous Substances Data)

Usage

General Description

2,4-dimethylphenylhydroxylamine is a chemical compound with the molecular formula C8H11NO. It is a colorless to pale yellow liquid with a strong amine-like odor. This chemical is primarily used as an intermediate in the production of pharmaceuticals and other organic compounds. It is also used as a stabilizer and antioxidant in polymers and plastics. 2,4-dimethylphenylhydroxylamine is a stable compound under normal conditions, but it should be handled with care due to its potential to cause skin and eye irritation. It is important to follow proper safety precautions when working with this chemical, including using appropriate personal protective equipment and working in a well-ventilated area.

InChI:InChI=1/C8H11NO/c1-6-3-4-8(9-10)7(2)5-6/h3-5,9-10H,1-2H3

Upstream product

• 89-87-2 2,4-dimethylnitrobenzene 

Downstream Products

• 99766-50-4 bis-(2,4-dimethyl-phenyl)-diazene-N-oxide 
• 622010-85-9 C₁₀H₁₃NO₂ 
• 69383-61-5 5-chloro-2,4-dimethylaniline 
• 63133-82-4 2-chloro-4,6-dimethylaniline 
• 95-68-1 2,4-Xylidine 
• 1198-37-4 2,4-dimethylquinoline 
• 615-90-7 2,5-dimethylhydroquinone 
• 41825-73-4 2-bromo-4,6-dimethylaniline 
• 408312-46-9 1,5-diethoxy-2,4-dimethyl-benzene 
• 105-67-9 2,4-Xylenol 
• 29418-25-5 bis-(2,4-dimethyl-phenyl)-diazene 
• 31058-43-2 1,4-diethoxy-2,5-dimethyl-benzene 
• 137-18-8 2,5-Dimethyl-1,4-benzoquinone 
• 26567-10-2 2,2'-dihydroxy-3,3',5,5'-tetramethylbiphenyl 

Relevant articles and documents

METHOD OF REDUCING AROMATIC NITRO COMPOUNDS

A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.

Synthesis, characterization, and conformational analysis of DNA adducts from methylated anilines present in tobacco smoke

The ability of a series of aromatic amines present in tobacco smoke (2-, 3-, and 4-methylaniline, 2,3- and 2,4-dimethylaniline) to bind to DNA has been investigated by reacting N-(acyloxy)arylamines with dG, dG nucleotides, and DNA. The predominant products from reactions with dG and the nucleotides were characterized as N-(deoxyguanosin-8-yl)arylamines by spectroscopic and HPLC methods. HPLC and spectroscopic analyses of the modified DNA indicated the same adducts. Analyses of the 1H and 13C NMR spectra suggested that the adducts containing a methyl substituent ortho to the arylamine nitrogen had a higher percentage of syn conformers. This observation was supported by theoretical simulation studies that indicated substantial percentages of low energy syn conformers, increasing with the substitution pattern in the order para meta ortho ortho,para ortho,meta. The results demonstrate that, although single-ring arylamines are considered weak carcinogens, their electrophilic N-acetoxy derivatives, which are plausible metabolic intermediates, react with DNA to yield covalent adducts structurally identical to those derived from carcinogenic polyarylamines, such as 2- aminofluorene and 4-aminobiphenyl. Furthermore, the conformational perturbation induced in DNA by the formation of the monoarylamine-DNA adducts, especially those with an ortho substituent, may contribute to the biological activities of these compounds.