70862-59-8

Basic information

• Product Name: 5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)isoxazole
• Synonyms: 5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)isoxazole
• CAS NO: 70862-59-8
• Molecular Weight: 261.176
• Mol File: 70862-59-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)isoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)isoxazole(70862-59-8)
• EPA Substance Registry System: 5-(3-fluoro-4-methoxyphenyl)-3-(trifluoromethyl)isoxazole(70862-59-8)

Safety Data

• Hazardous Substances Data: 70862-59-8(Hazardous Substances Data)

Upstream product

• 753-90-2 trifluoroethylamine 
• 120136-28-9 3-fluoro-4-methoxyphenylacetylene 
• 70862-63-4 4,4,4-trifluoro-1-(3-fluoro-4-methoxyphenyl) butane-1,3-dione 

Relevant articles and documents

Cu-Catalyzed Synthesis of Fluoroalkylated Isoxazoles from Commercially Available Amines and Alkynes

A one-pot protocol for the construction of fluoroalkylated isoxazoles directly from commercially available amines and alkynes is described. The reaction is scalable, operationally simple, regioselective, mild, and tolerant of a broad range of functional groups. As such, it could be viewed as a click synthesis of fluoroalkylated isoxazoles. Preliminary mechanistic investigations reveal that the transformation involves an unprecedented Cu-catalyzed cascade sequence involving RfCHN2.