70862-67-8

Upstream product

• 83-07-8 4-amino-2,3-dimethyl-1-phenylpyrazolin-5-one 
• 105-39-5 chloroacetic acid ethyl ester 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 151921-25-4 1-furfurylidene-4-(N-antipyrinylglycyl)-3-thiosemicarbazone 
• 151921-15-2 1-[3-Chloro-2-(2-chloro-phenyl)-4-oxo-azetidin-1-yl]-3-[2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-acetyl]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 151921-16-3 1-[3-Chloro-2-oxo-4-((E)-styryl)-azetidin-1-yl]-3-[2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-acetyl]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 151921-14-1 1-(3-Chloro-2-oxo-4-phenyl-azetidin-1-yl)-3-[2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-acetyl]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 151921-11-8 1-{[1-(2-Chloro-phenyl)-meth-(E)-ylidene]-amino}-3-[2-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-acetyl]-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 151921-10-7 1-[2-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-acetyl]-3-{[1-phenyl-meth-(E)-ylidene]-amino}-2-thioxo-dihydro-pyrimidine-4,6-dione 
• 151921-24-3 1-allylphenylidene-4-(N-antipyrinyl-glycyl)-3-thiosemicarbazone 
• 151921-22-1 1-(benzylidene)-4-(N-antipyrinylglycyl)-3-thiosemicarbazone 
• 151921-23-2 1-(o-chlorobenzylidene)-4-(N-antipyrinyl glycyl)-3-thiosemicarbazone 

Relevant academic research and scientific papers

Synthesis and biological activity studies of some new hybrid compounds derived from antipyrine

N-Benzyl-N'-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)urea (1) was obtained from antipyrine. The reaction of 1 with ethyl bromoacetate produced the 1,3-oxazole derivative 2. Compounds 5a-c were obtained from antipyrine by three steps via in

Novel pyrazole derivatives as anticancer and radiosensitizing agents

The present article describes the synthesis of some novel pyrrole, pyrazolo[4,3-d]oxazole, pyrrolo[2,3-b]pyridine, 1,2,3-triazole and oxoazetidin derivatives incorporating pyrazole moiety, the structures of which were confirmed by elemental analyses and s

Antipyrine congeners as antidepressant agents

1-(N-Antipyrinylglycyl)-3-arylideneamino)-2-thiobarbituric acids (III) were synthesized from 1-arylidene-4-(N-antipyrinyl glycyl)-3-thiosemicarbazones (II). Compounds II in turn were prepared from 4-amino antipyrine. Compounds III were finally converted into 1-(N-antipyrinylglycyl)-3-[(3'-chloro-4-aryl) azitidinyl]-2-thiobarbituric acids (IV). 4-Aminoantipyrine was also treated with different N-protected amino acids in the presence of N,N'-dicyclohexylcarbodiimide to yield N-(antipyrinylcarbamoyl) substituted alkyl benzamides (V); their debenzoylation yielded 2-(amino-N-antipyrinyl) substituted acetamides (VI). The compounds were screened for their antidepressant activity. Compounds IIId, Va and Vb exhibited activity better than imipramine with less toxicity (ALD50 > 1000 mg/kg).