70889-93-9

Upstream product

• 24123-14-6 N-(2-Aminoethyl)glycine 
• 13795-24-9 benzyl 4-nitrophenyl carbonate 
• 501-53-1 benzyl chloroformate 
• 3560-45-0 benzyl-{2-[(2-hydroxyethyl)amino]ethyl}carbamate 
• 81225-86-7 [Benzyloxycarbonyl-(2-benzyloxycarbonylamino-ethyl)-amino]-acetic acid 

Downstream Products

• 143192-38-5 {(2-Benzyloxycarbonylamino-ethyl)-[(S)-2-tert-butoxycarbonylamino-3-(1-formyl-1H-indol-3-yl)-propionyl]-amino}-acetic acid methyl ester 
• 143192-36-3 [(2-Benzyloxycarbonylamino-ethyl)-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionyl)-amino]-acetic acid methyl ester 
• 143192-37-4 [(2-Benzyloxycarbonylamino-ethyl)-((S)-2-tert-butoxycarbonylamino-4-methyl-pentanoyl)-amino]-acetic acid methyl ester 

Relevant academic research and scientific papers

Preparation method N - (2 - aminoethyl) glycine derivative

The N - (2 - aminoethyl) glycine derivative product compound is obtained by taking hydroxyethyl ethylenediamine as a raw material, Cbz protecting the primary amine and then oxidizing the reaction, and N - (2 - aminoethyl) glycine derivative. To the prepar

Building Units for N-Backbone Cyclic Peptides. 1. Synthesis of Protected N-(ω-Aminoalkylene)amino Acids and Their Incorporation into Dipeptide Units

A variety of new amino acids which contain an ω-aminoalkylene group on the Nα-amino nitrogen were synthesized by alkylation of alkylenediamines with α-halogeno acids.The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active α-halogeno acids were used.The N-(ω-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology.A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by ω-aminoalkylene chains with various lengths were prepared.These new protected N-(ω-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.

Aminoethylglycine containing polypeptides

Novel somatostatin analogues containing one or more aminoethylglycyl residues at the amino and/or carboxyl terminus or in the ring position are described. The compounds are potent and long lasting inhibitors of gastric acid secretion.