709-06-8Relevant articles and documents
2-Aminoquinazolines by Chan-Evans-Lam Coupling of Guanidines with (2-Formylphenyl)boronic Acids
Solomin, Vitalii V.,Seins, Alberts,Jirgensons, Aigars
supporting information, p. 1507 - 1510 (2020/07/24)
A new method is presented for the synthesis of 2-aminoquinazolines, which is based on a Chan-Evans-Lam coupling of (2-formylphenyl)boronic acids with guanidines. Relatively mild conditions involving the use of inexpensive CuI as a catalyst and methanol as a solvent permit the application of the method to a wide range of substrates. Nonsubstituted, N-monosubstituted, and N,N-disubstituted guanidines can be used as reactants to give the corresponding 2-aminoquinazolines in moderate yields from readily available (2-formylphenyl)boronic acids.
Tetrodotoxin.
Goto,Kishi,Takahashi,Hirata
, p. 2059 - 2088 (2007/10/04)
-