70924-78-6

Basic information

• Product Name: TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE
• Synonyms: TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE;TRANS-1,2-BIS(ACETAMIDO)CYCLOHEXANE;trans-N,N'-Diacetylcyclohexane-1,2-diamine
• CAS NO: 70924-78-6
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.26
• Mol File: 70924-78-6.mol

Chemical Properties

• Melting Point: 270 °C
• Boiling Point: 469.1±25.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Solubility: soluble in Methanol
• PKA: 15.29±0.40(Predicted)
• CAS DataBase Reference: TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE(70924-78-6)
• EPA Substance Registry System: TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE(70924-78-6)

Safety Data

• Hazardous Substances Data: 70924-78-6(Hazardous Substances Data)

Usage

Uses

Used in Polymer and Resin Synthesis:
TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE is used as a crosslinking agent in the synthesis of polymers and resins. Its ability to form covalent bonds between polymer chains enhances the mechanical properties and stability of the resulting materials.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE is utilized for its potential applications in drug development. Its chemical properties allow it to be incorporated into the structure of various pharmaceutical compounds, potentially improving their efficacy and stability.
Used as a Reagent in Organic Chemical Reactions:
TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE serves as a reagent in various organic chemical reactions. Its unique chemical structure enables it to participate in a range of reactions, facilitating the synthesis of complex organic molecules and contributing to the advancement of organic chemistry.
Safety Precautions:
Although TRANS-N,N'-DIACETYLCYCLOHEXANE-1,2-DIAMINE is not considered to be highly toxic, it is essential to handle it with care and follow proper safety measures during its use. This includes wearing appropriate personal protective equipment, working in a well-ventilated area, and adhering to established safety protocols to minimize potential health risks.

Upstream product

• 1121-22-8 trans-1,2-Diaminocyclohexane 
• 108-24-7 acetic anhydride 

Relevant articles and documents

Stereochemical studies of 1,2-Di(thio)acetamido-cyclohexanes and their N,N′-dimethyl derivatives by NMR and CD spectroscopy and by molecular mechanics calculations

The configurations and conformations of cis- and trans- 1,2-di (thio)acetamidocyclohexane and their N,N′-dimethyl derivatives have been studied by 1H and 13C NMR spectroscopy, using chemical shifts and coupling constants, difference NOE 1H NMR spectra and 2D 1H-13C NMR correlation spectra. For the trans compounds, the Z,Z configuration of the (thio)amide groups with equatorial (thio)acetamido groups was found to be strongly preferred. For the cis compounds, E,Z configurations of the (thio)amide groups with axial E and equatorial Z groups were found to be preferred. Empirical force-field calculations with the MM2(91) force field led to predictions for the most stable configurations and conformations, mostly in very good agreement with those obtained by NMR spectroscopy. CD spectra recorded for the trans-(R,R)-N-methyl compounds in acetonitrile solution agreed well with those calculated on the basis of geometries from force-field calculations. The CD spectra calculated for the trans-(R,R)-NH- compounds and for the cis-monothio compounds showed poor agreement with the experimental spectra. Acta Chemica Scandinavica 1996.

Bifunctional Chiral Auxiliaries 5: The Synthesis of 1,3-Diacylimidazolidine-2-thiones and 1,3-Diacylimidazolidin-2-ones from 1,2-Diamines

Although 1,2-diamines fail to cyclise with urea, phosgene or 1,1'-carbonyl diimidazole, they react with carbon disulphide to give the corresponding imidazolidine-2-thiones.These undergo clean diacylation to give 1,3-diacylimidazolidine-2-thiones which are