70932-38-6

Basic information

• Product Name: 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-α-L-galactopyranose
• Synonyms: 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-α-L-galactopyranose
• CAS NO: 70932-38-6
• Molecular Weight: 414.477
• Mol File: 70932-38-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-α-L-galactopyranose(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-α-L-galactopyranose(70932-38-6)
• EPA Substance Registry System: 1,2:3,4-di-O-isopropylidene-6-O-(p-toluenesulfonyl)-α-L-galactopyranose(70932-38-6)

Safety Data

• Hazardous Substances Data: 70932-38-6(Hazardous Substances Data)

Upstream product

• 1668-08-2 L-galactono-1,4-lactone 
• 4064-06-6 1,2:3,4-di-O-isopropylidene-α-L-galactopyranose 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 6619-07-4 Toluene-4-sulfonic acid (2S,3S,4R,5S)-3,4,5,6-tetrahydroxy-tetrahydro-pyran-2-ylmethyl ester 
• 138332-00-0 6-azido-L-galactose 
• 245343-35-5 4-{2-Benzyloxy-1-benzyloxymethyl-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-ethylcarbamoyl}-butyric acid benzyl ester 
• 188825-37-8 {2-Benzyloxy-1-benzyloxymethyl-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 184005-57-0 N-{(S)-5-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-pentyl}-succinamic acid 
• 245343-33-3 4-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-propylcarbamoyl}-butyric acid 
• 188825-39-0 N-{(1S,2R)-3-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-propyl}-succinamic acid 
• 184005-55-8 {(S)-5-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-pentyl}-carbamic acid tert-butyl ester 
• 188825-35-6 {(1S,2R)-3-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-propyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its FcγReceptor Affinity and ADCC Activity

Fc glycosylation profoundly impacts the effector functions of antibodies and often dictates an antibody's pro- or anti-inflammatory activities. It is well established that core fucosylation of the Fc domain N-glycans of an antibody significantly reduces i

Fluorescently labeled substrates for monitoring α1,3- fucosyltransferase IX activity

Fucosylation is often the final process in glycan biosynthesis. The resulting glycans are involved in a variety of biological processes, such as cell adhesion, inflammation, or tumor metastasis. Fucosyltransferases catalyze the transfer of fucose residues from the activated donor molecule GDP-β-L-fucose to various acceptor molecules. However, detailed information about the reaction processes is still lacking for most fucosyltransferases. In this work we have monitored α1,3-fucosyltransferase activity. For both donor and acceptor substrates, the introduction of a fluorescent ATTO dye was the last step in the synthesis. The subsequent conversion of these substrates into fluorescently labeled products by α1,3-fucosyltransferases was examined by high-performance thin-layer chromatography coupled with mass spectrometry as well as dual-color fluorescence cross-correlation spectroscopy, which revealed that both fluorescently labeled donor GDP-β-L-fucose-ATTO 550 and acceptor N-acetyllactosamine-ATTO 647N were accepted by recombinant human fucosyltransferase IX and Helicobacter pylori α1,3- fucosyltransferase, respectively. Analysis by fluorescence cross-correlation spectroscopy allowed a quick and versatile estimation of the progress of the enzymatic reaction and therefore this method can be used as an alternative method for investigating fucosyltransferase reactions. Fucosyl transfer: Two substrates of α1,3-fucosyltransferase IX have been labeled with ATTO dyes to monitor the enzymatically catalyzed transfer of the sugar moiety (see figure). The labeled guanosine diphosphate-fucose derivative was prepared by using cycloSal technology. The successful transfer reaction was first proven by high-performance thin-layer chromatography coupled with mass spectrometry. Fluorescence cross-correlation spectroscopy proved to be a suitable method for monitoring the enzyme activity.

Synthese neuartiger 6-Amido-6-desoxy-L-galactose-Derivate als potente Sialyl-Lewisx-Mimetica

Keywords: Glycopeptide; Selectine; Sialyl-Lewisx