7095-33-2Relevant academic research and scientific papers
Structural characterization of phenolic constituents from the rhizome of Imperata cylindrica var. major and their anti-inflammatory activity
Cao, Hui-Na,Han, Yu,Hao, Mi-Mi,Jiang, Hong-Yu,Li, Hui-Min,Ruan, Jing-Ya,Wang, Tao,Zhang, Yi,Zhang, Ying,Zhao, Wei
, (2022/01/19)
As one of raw materials, the rhizome of Imperata cylindrica var. major (Nees) C.E. Hubb. is used in kinds of preparations curing inflammation related diseases, while its effective substances are not yet clear. In this paper, its chemical constituents and their anti-inflammatory activities were investigated. As results, ten compounds, named as imperphenoside A (1), imperphenols B (2) and C (3), imperphenosides D–F (4–6), and imperlignanosides A–D (7–10), along with previously reported thirty-seven known ones (11–47) were obtained from it. Their structures were ascertained basing on the extensive spectroscopic methods and electronic circular dichroism data analysis. Meanwhile, compounds 4, 11, 12, 24, 27, 31, 32, 37, 43, 45, and 47 exhibited nitric oxide inhibitory effects in concentration dependent at 3, 10, and 30 μM on lipopolysaccharides induced RAW 264.7 cells. Moreover, the western blot analysis indicated that compounds 4, 11, 43, and 47 could restrain the phosphorylation of nuclear factor kappa-B kinase to down-regulate the protein expression of inflammatory cytokines such as inducible nitric oxide synthase, interleukin-6 and tumor necrosis factor-α. In conclusion, they might play the anti-inflammatory effects through regulating NF-κB signaling pathway.
Anti-inflammatory terpenes from Schefflera rubriflora C. J. Tseng & G. Hoo with their TNF-α and IL-6 inhibitory activities
Li, Fenghua,Zhang, Jian,Lin, Mingbao,Su, Xianming,Li, Changkang,Wang, Hongqing,Li, Baoming,Chen, Ruoyun,Kang, Jie
, p. 23 - 32 (2019/04/26)
The 95% ethanol extract and its EtOAc and n-BuOH fractions obtained from the leaves and twigs of Schefflera rubriflora C. J. Tseng & G. Hoo showed significant inhibitory activities (33.6%, 35.7% and 40.6%, respectively) against croton oil-induced ear inflammation in mice. Bioactivity-guided isolation and separation gave eight previously undescribed terpenes or terpene glycosides. Structural elucidation was based on UV, IR, and NMR spectroscopy, MS, experimental and calculated ECD data, and Mosher's method. To identify anti-inflammatory components from the extract, all the compounds were evaluated for tumor necrosis factor-α (TNF-α) and interleukine-6 (IL-6) inhibitory activities. Four undescribed compounds inhibited mRNA expression of TNF-α and IL-6 with IC50 values of 15.3–52.4 μM.
New CuCl2-induced glucoside esters and other constituents from Portucala oleracea
Wu, Bin,Yu, Liyan,Wu, Xiaodan,Chen, Jianbo
body text, p. 68 - 73 (2012/04/11)
Two new glucoside esters 1 and 2 were produced as stress metabolites in the fresh leaves of Portulaca oleracea, in response to abiotic stress elicitation by CuCl2. A new sugar ester (3) and two known compounds (4 and 5) were also isolated. Their structures were established by spectroscopic means. The antioxidative activities of stress metabolites and the related isolates were evaluated by DPPH assay. The results showed that new stress-driven adducts of monolignans and monoterpenes with a glucose bridge exhibited much stronger antioxidative activities than other compounds.
Glycosides from the root of Iodes cirrhosa
Gan, Maoluo,Zhang, Yanling,Lin, Sheng,Liu, Mingtao,Song, Weixia,Zi, Jiachen,Yang, Yongchun,Fan, Xiaona,Shi, Jiangong,Hu, Jinfeng,Sun, Jiandong,Chen, Naihong
experimental part, p. 647 - 654 (2009/04/04)
Seven new neolignan glycosides (1-7), two arylglycerol glycosides (8, 9), and 18 known glycosides have been isolated from an ethanolic extract of the root of Iodes cirrhosa. Their structures including absolute configurations were determined by spectroscop
Enantioselective synthesis of phenylpropanetriols
DellaGreca, Marina,Fiorentino, Antonio,Monaco, Pietro,Previtera, Lucio
, p. 3693 - 3700 (2007/10/03)
The four stereomer 1-(4-hydroxy-3-methoxy)-phenyl-1,2,3-propanetriols were obtained in about 30% yields starting from ferulic acid by synthesis based on osmium catalyzed asymmetric dihydroxylation.
Studies on the constituents of Osmanthus species. X. Structures of phenolic glucosides from the leaves of Osmanthus asiaticus NAKAI
Sugiyama,Kikuchi
, p. 325 - 326 (2007/10/02)
Three new phenolic glucosides were isolated from the leaves of Osmanthus asiaticus NAKAI (Oleaceae). The structures of 1, 2 and 3 were determined to be 2-hydroxy-5-(2-hydroxyethyl)phenyl β-D-glucopyranoside, 4-(2,3-dihydroxypropyl)-2,6-dimethoxyphenyl β-D-glucopyranoside and D-threo-guaiacylglycerol 7-O-β-D-glucopyranoside, respectively, on the basis of chemical and spectral data.
PHENOLIC GLUCOSIDE GALLATES FROM QUERCUS MONGOLICA AND Q. ACUTISSIMA
Ishimaru, Kanji,Nonaka, Gen-Ichiro,Nishioka, Itsuo
, p. 1147 - 1152 (2007/10/02)
Six phenolic glucoside gallates: D-threo-guaiacylglycerol 8-O-, L-threo-guaiacylglycerol 8-O-, 3-methoxy-4-hydroxyphenol 1-O-, gentisic acid 5-O, 3,5-dimethoxy-4-hydroxyphenol 1-O- and cis-coniferyl alcohol 4-O-β-D-(6'-O-galloyl)glucopyranosides were isolated from Quercus mongolica and Q. acutissima. - Key Word Index: Quercus mongolica; Q. acutissima; Fagaceae; phenolic glucoside gallates; D-threo-guaiacylglycerol; L-threo-guaiacylglycerol; 3-methoxy-4-hydroxyphenol; gentisic acid; 3,5-dimethoxy-4-hydroxyphenol; cis-coniferyl alcohol.
