709656-07-5

Upstream product

• 5333-86-8 ethyl benzimidate hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 99184-99-3 2-phenyloxazoline-4-carboxylic acid 
• 116956-53-7 sodium 2-phenyloxazoline-4-carboxylate 
• 100-47-0 benzonitrile 
• 55044-06-9 methyl 2-phenyl-2-oxazoline-4-carboxylate 
• 65-85-0 benzoic acid 

Downstream Products

• 721401-61-2 (S)-4-benzyl-2-phenyl-4,5-dihydro-oxazole-4-carboxylic acid tert-butyl ester 
• 1065062-26-1 C₁₇H₂₁NO₃ 
• 1065062-29-4 C₁₇H₁₉NO₃ 
• 1065062-21-6 C₁₅H₁₉NO₃ 
• 1613450-03-5 tert-butyl 2-phenyl-4-propyloxazoline-4-carboxylate 
• 1613449-98-1 tert-butyl 2-(benzylamino)-2-(hydroxymethyl)butanoate 
• 1613450-04-6 tert-butyl 2-(benzylamino)-2-(hydroxymethyl)pentanoate 
• 1613450-05-7 tert-butyl 2-benzyl-2-(benzylamino)-3-hydroxypropanoate 
• 1613449-99-2 tert-butyl 3-benzyl-4-ethyl-2-oxo-1,2,3-oxathiazolidine-4-carboxylate 
• 1613450-07-9 tert-butyl 3-benzyl-2-oxo-4-propyl-1,2,3-oxathiazolidine-4-carboxylate 
• 1613450-08-0 tert-butyl 3,4-dibenzyl-2-oxo-1,2,3-oxathiazolidine-4-carboxylate 
• 1613450-09-1 tert-butyl 3-benzyl-4-(4-fluorobenzyl)-2-oxo-1,2,3-oxathiazolidine-4-carboxylate 
• 1613450-00-2 tert-butyl 3-benzyl-4-ethyl-2,2-dioxo-1,2,3-oxathiazolidine-4-carboxylate 
• 1613450-10-4 tert-butyl 3-benzyl-2,2-dioxo-4-propyl-1,2,3-oxathiazolidine-4-carboxylate 

Relevant academic research and scientific papers

Synthesis of protected α-alkyl lanthionine derivatives

Protected α-alkyl lanthionine derivatives were synthesized in five steps starting from a known phenyloxazoline precursor. This approach involved the synthesis of a family of substituted cyclic sulfamidates and their regioselective opening by nucleophilic attack with a protected cysteine. This efficient multistep strategy affords various α-alkylated lanthionine derivatives in high yields.

Highly enantioselective synthesis of (R)-α-alkylserines via phase-transfer catalytic alkylation of o-biphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester using cinchona-derived catalysts

(Chemical Equation Presented) A highly enantioselective synthetic method for (R)-α-alkylserines was developed by the phase-transfer catalytic alkylation of obiphenyl-2-oxazoline-4-carboxylic acid tert-butyl ester (4i) using cinchona-derived phase-transfer

An unusual base-dependent α-alkylation and β-elimination of tert-butyl 2-phenyl-2-oxazoline-4-carboxylate: Practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate

Practical synthesis of (±)-α-alkylserines and tert-butyl benzamidoacrylate from tert-butyl 2-phenyl-2-oxazoline-4-carboxylate (6) were developed. The α-alkylation and β-elimination of 6 are dramatically dependent upon base conditions. The phase-transfer catalytic condition bearing solid KOH in toluene gives α-alkylation (up to >99%), and t-BuOK in DMF gives β-elimination (98%).