70967-79-2Relevant academic research and scientific papers
INSULIN RECEPTOR PARTIAL AGONISTS
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Page/Page column 100-102; 103, (2022/03/09)
Insulin dimers and insulin analog dimers that act as partial agonists at the insulin receptor are disclosed.
MODULATORS OF G-PROTEIN COUPLED RECEPTORS
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Page/Page column 151-152, (2019/10/15)
This disclosure features chemical entities (e.g., a compound or a pharmaceutically acceptable salt and/or hydrate and/or prodrug of the compound) that modulate (e.g., agonize or partially agonize or antagonize) glucagon?like peptide?1 receptor ("GLP?1R") and/or the gastric inhibitory polypeptide receptor ("GIPR"). The chemical entities are useful, e.g., for treating a subject (e.g., a human) having a disease, disorder, or condition in which modulation (e.g., agonism, partial agonism or antagonism) of GLP?1R and/or GIPR activities is benficial for the treatment or prevention of the underlying pathology and/or symptoms and/or progression of the disease, disorder, or condition. In some embodiments, the modulation results in an enhancment of (e.g., an increase in) existing levels (e.g., normal or below normal levels) of GLP?1R and/or GIPR activity (e.g., signaling). In some embodiments, the chemical entities described herein further modulate (e.g., attenuate, uncouple) -arrestin signaling relative to what is observed with the native ligand. This disclosure also features compositions as well as other methods of using and making the said chemical entities.
INSULIN RECEPTOR PARTIAL AGONISTS AND GLP-1 ANALOGUES
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Page/Page column 143, (2017/12/29)
The present invention provides compositions comprising insulin receptor partial agonists in association with GLP-1 analogues (e.g., liraglutide) as well as methods for using the compositions for example, to treat or prevent diabetes or to decrease body weight.
USE OF ORGANIC OXYIMIDES AS FLAME RETARDANT FOR PLASTIC MATERIALS AND ALSO FLAME-RETARDANT PLASTIC MATERIAL COMPOSITION AND MOULDED PARTS PRODUCED THEREFROM
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Paragraph 0179-0181, (2016/05/02)
The present invention relates to the use of organic oxy imides as flame retardants for plastics. According to the present invention, a flame-retardant plastics composition is likewise specified, including an oxy imide as flame retardant. Additionally specified are mouldings produced from an inventive flame-retardant polymer composition.
Multinuclear non-heme iron complexes for double-strand DNA cleavage
Megens, Rik P.,Van Den Berg, Tieme A.,De Bruijn, A. Dowine,Feringa, Ben L.,Roelfes, Gerard
supporting information; experimental part, p. 1723 - 1733 (2009/10/06)
The cytotoxicity of the antitumor drug BLM is believed to be related to the ability of the corresponding iron complex (Fe-BLM) to engage in oxidative double-strand DNA cleavage. The iron complex of the ligand N4Py (Fe-N4Py; N4Py = N,N-bis(2-pyridyl)-N-bis
MYCOPHENOLIC ACID IMMUNOGENS AND ANTIBODIES
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Page/Page column 9, (2009/06/27)
Described are immunogenic compounds useful for generation of antibodies which are highly specific for mycophenolic acid which do not react or have substantially no cross-reactivity with the glucuronide metabolites of mycophenolic acid, especially the acyl
Reagents for detecting efavirenz
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Page/Page column 8, (2010/02/08)
The invention provides derivatives of efavirenz and methods of making derivatives of efavirenz. The derivatives include immunogenic compounds for producing antibodies to efavirenz and labeled efavirenz tracers. These compounds are useful in immunoassay me
