70968-22-8Relevant articles and documents
Methionine analogues as inhibitors of methionyl-tRNA synthetase
Lee, Jeewoo,Kang, Mee Kyoung,Chun, Moon Woo,Jo, Yeong Joon,Kwak, Jin Hwan,Kim, Sunghoon
, p. 3511 - 3514 (1998)
A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.