Bioorganic and Medicinal Chemistry Letters p. 3511 - 3514 (1998)
Update date:2022-08-02
Topics:
Lee, Jeewoo
Kang, Mee Kyoung
Chun, Moon Woo
Jo, Yeong Joon
Kwak, Jin Hwan
Kim, Sunghoon
A series of methionine analogues have been synthesized as inhibitors of methionyl-tRNA synthetase and evaluated for their inhibitory activities of E. coli methionyl-tRNA synthetase and bacterial growth. Among them, L-methionine hydroxamate 20 has proved to be the best inhibitor of the enzyme with K(i) = 19 μM and showed a growth inhibition against E. coli JM 109, P. vulganis 6059 and C. freundii 8090.
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