70975-30-3Relevant academic research and scientific papers
Asymmetric hydrogenation of alkynyl ketones with the η6- arene/TsDPEN-ruthenium(II) catalyst
Arai, Noriyoshi,Satoh, Hironori,Utsumi, Noriyuki,Murata, Kunihiko,Tsutsumi, Kunihiko,Ohkuma, Takeshi
supporting information, p. 3030 - 3033 (2013/07/26)
Enantioselective hydrogenation of alkynyl ketones catalyzed by Ru(OTf)(TsDPEN)(η6-p-cymene) (TsDPEN = N-(p-toluenesulfonyl)-1,2- diphenylethylenediamine) affords the propargylic alcohols in up to 97% ee. The alkynyl moieties are left intact in most cases. The reaction can be conducted with a substrate-to-catalyst molar ratio as high as 5000 under 10 atm of H 2. The mode of enantioselection is elucidated with the transition state models directed by the CH/π attractive interaction between the substrate and the catalytic species.
Developing asymmetric iron and ruthenium-based cyclone complexes; Complex factors influence the asymmetric induction in the transfer hydrogenation of ketones
Hopewell, Jonathan P.,Martins, Jose E. D.,Johnson, Tarn C.,Godfrey, Jamie,Wills, Martin
experimental part, p. 134 - 145 (2012/01/12)
The preparation of a range of asymmetric iron and ruthenium-cyclone complexes, and their application to the asymmetric reduction of a ketone, are described. The enantioselectivity of ketone reduction is influenced by a single chiral centre in the catalyst, as well as by the planar chirality in the catalyst. This represents the first example of asymmetric ketone reduction using an iron cyclone catalyst.
