70978-39-1

Usage

Uses

Used in Pharmaceutical Synthesis:
5'-FLUORO-2'-HYDROXY-3'-NITROis used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique functional groups allow for further chemical reactions and modifications, leading to the development of new drugs with improved therapeutic properties.
Used in Organic Synthesis:
In the field of organic synthesis, 5'-FLUORO-2'-HYDROXY-3'-NITROis used as a versatile building block for the preparation of a wide range of organic compounds. Its reactivity and functional groups make it suitable for various synthetic routes, enabling the creation of complex molecules with diverse applications.
Used in Catalyst Preparation:
5'-FLUORO-2'-HYDROXY-3'-NITROcan be used in the preparation of catalysts for various chemical reactions. Its ability to participate in catalytic cycles and its stability under certain reaction conditions make it a promising candidate for the development of new catalysts.
Used in the Preparation of 1-(3-amino-5-fluoro-2-hydroxyphenyl)ethanone:
5'-FLUORO-2'-HYDROXY-3'-NITROis used as a starting material to prepare 1-(3-amino-5-fluoro-2-hydroxyphenyl)ethanone via catalytic hydrogenation. This transformation allows for the synthesis of a new compound with potential applications in various fields, such as pharmaceuticals or materials science.

Preparation

Preparation by nitration of 5-fluoro-2-hydroxy-acetophenone with nitric acid (d = 1.42) in concentrated sulfuric acid between ?15° and ?5° (46%).

InChI:InChI=1/C8H6FNO4/c1-4(11)6-2-5(9)3-7(8(6)12)10(13)14/h2-3,12H,1H3

Upstream product

• 394-32-1 1-(5-fluoro-2-hydroxyphenyl)ethan-1-one 

Downstream Products

• 698985-45-4 1-nitro-2,3-dihydroxy-5-fluorobenzene 
• 1443367-13-2 6-chloro-8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-12-1 6-chloro-8-(4-nitrobenzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-11-0 6-chloro-8-(3-methylbenzamido)-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-10-9 8-benzamido-6-chloro-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-09-6 C₁₈H₁₂FNO₆ 
• 1443367-08-5 8-(3,4-dichlorobenzamido)-6-fluoro-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-07-4 8-(2,4-dichlorobenzamido)-6-fluoro-4-oxo-4H-chromene-2-carboxylic acid 
• 1443367-06-3 8-(2,3-dichlorobenzamido)-6-fluoro-4-oxo-4H-chromene-2-carboxylic acid 
• 1443366-78-6 ethyl 6-Chloro-8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-77-5 ethyl 6-chloro-8-(4-nitrobenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-76-4 ethyl 6-chloro-8-(3-methylbenzamido)-4-oxo-4H-chromene-2-carboxylate 
• 1443366-75-3 ethyl 8-benzamido-6-chloro-4-oxo-4H-chromene-2-carboxylate 

Relevant academic research and scientific papers

ANTI-INFECTIVE AGENTS

The present invention relates to a novel class of chromene-2-carboxamide compounds inhibitors of general formula (I) wherein R1, R2, R3, R4, R5, R6, R7, R8 and X are as defined herein, to their use in medicine, and their use as anti-infective agents in particular, to compositions containing them, to processes for their preparation and to intermediates used in such processes.

SUBSTITUTED IMIDAZO[1,2-a]PYRIDINE COMPOUNDS AS TROPOMYOSIN RECEPTOR KINASE A (TrkA) INHIBITORS

The present application relates to a series of substituted imidazo[1,2-a]pyridine compounds of formula (I), pharmaceutically acceptable salts, pharmaceutically acceptable solvates or stereoisomers thereof, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

MULTIPLE D2 A(NTA)GONISTS/H3 ANTAGONISTS FOR TREATMENT OF CNS-RELATED DISORDERS

The present invention relates to compounds compound according to Formula (III); and pharmaceutically acceptable salts, hydrates and solvates thereof. These compounds have D2receptor antagonist/(partial) agonist effects and H3antagonistic effects, pharmaceutical compositions thereof, and methods of using them for application in the prophylaxis or treatment of CNS disorders.

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors, method of making and pharmaceutical compositions comprising such compounds.

SUBSTITUTED PYRAZOLO[1,5-A] PYRIDINE AS TROPOMYOSIN RECEPTOR KINASE (TRK) INHIBITORS

The present application relates to a series of substituted pyrazolo[1,5-a]pyridine compounds, their use as tropomyosin receptor kinase (Trk) family protein kinase inhibitors., method of making and pharmaceutical compositions comprising such compounds.

Synthesis of 7-substituted-(2,3-dihydro-1,4-benzodioxin-5-yl)-piperazine

A simple and versatile method for the synthesis of 7-substituted (2,3-dihydro-1,4-benzodioxin-5-yl)-piperazines starting from easy available class of derivatives has been developed. Copyright Taylor & Francis Group, LLC.

Benzopyran derivatives having leukotriene-antagonistic action

The present invention relates to novel 4-oxo-4H-1-benzopyran compounds containing benzyloxymethyl, 3-phenylpropyl, or other araliphatic substituents in their 8-position. These compounds show a leukotriene-antagonistic activity. The compounds are characterized by good oral adsorption. The compounds of the present invention may be used as anti-inflammatory and antiallergic medicaments, and in the treatment of cardiovascular diseases.

2'Hydroxy tetrazole-5-carboxanilides and anti-allergic use thereof

New tetrazole derivatives of the general formula: STR1 [wherein R1 represents a halogen atom, a straight- or branched-chain alkyl, alkoxy, alkylthio, alkylsulphinyl, alkylsulphonyl or alkylsulphamoyl group, each such group containing from 1 to 6 carbon atoms, a dialkylsulphamoyl, dialkylamino, or dialkylcarbamoyl group (wherein the two alkyl groups may be the same or different and each contains from 1 to 4 carbon atoms), a straight- or branched-chain alkanoyl, alkoxycarbonyl, alkoxycarbonylamino, alkylcarbamoyl or alkanoylamino group containing from 2 to 6 carbon atoms, a cycloalkylcarbonyl group containing from 3 to 8 carbon atoms in the cycloalkyl moiety, or a hydroxy, formyl, nitro, trifluoromethyl, trifluoroacetyl, aryl, benzyloxycarbonylamino, amino, sulphamoyl, cyano, tetrazol-5-yl, carboxy, carbamoyl, benzyloxy, aralkanoyl or aroyl group, or a group of the formula: (wherein R2 represents a hydrogen atom or a straight- or branched-chain alkyl group containing from 1 to 5 carbon atoms, an aryl, aralkyl or trifluoromethyl group, or a cycloalkyl group containing from 3 to 8 carbon atoms, and R3 represents a hydrogen atom, or a straight- or branched-chain alkyl group containing from 1 to 6 carbon atoms optionally substituted by a phenyl group, or represents an aryl group optionally substituted by one or more substituents selected from halogen atoms and straight- or branched-chain alkyl and alkoxy groups containing from 1 to 6 carbon atoms and hydroxy, trifluoromethyl and nitro groups), and m represents zero or an integer 1, 2 or 3, the substituents R1 being the same or different when m represents 2 or 3] possess pharmacological properties, in particular properties of value in the treatment of allergic conditions.

Substituted alkylaryl ketones and methods of use as herbicides

Ring and side chain substituted alkylaryl ketones are useful in controlling the growth of germinating and seedling weed grasses and germinating and seedling broadleaf weeds.