70977-72-9Relevant articles and documents
Novel preparation method of 3-amino-2-hydroxyacetophenone
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Paragraph 0017; 0019, (2017/08/31)
The invention provides a novel preparation method of 3-amino-2-hydroxyacetophenone. The novel preparation method comprises the following steps of using 2-aminophenol as an initial raw material; enabling the 2-aminophenol and acetic anhydride to synthesize 2-acetamidophenol acetate in a polar solvent under the alkaline or acid catalyzing condition; then, performing Fries rearrangement on the 2-acetamidophenol acetate in an aprotic solvent under the catalyzing action of anhydrous titanium tetrachloride, and adopting an acid hydrolysis one-pot method, so as to synthesize the 3-amino-2-hydroxyacetophenone. The novel preparation method has the advantages that the price of the used raw materials is low, the obtaining is easy, and the selection of the raw materials is diversified; the implementing of the production technology is easy, the management and control are easy, the purity of a final product is high, the dangerous technology is avoided, the equipment is simple, the synthesizing route is novel and short, the production capacity is increased, and the production and processing cost is reduced.
New preparation method of 3-amino-2-hydroxyphenylacetone
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Paragraph 0014, (2017/08/29)
The invention discloses a new preparation method of a key intermediate, namely 3-amino-2-hydroxyphenylacetone, for preparation of Pranlukast. The new preparation method comprises the following main steps: taking 2-aminophenol-4-sulfonic acid as a starting raw material, and carrying out acylation, Fries rearrangement, hydrolysis and deprotection, so that 3-amino-2-hydroxyphenylacetone is obtained. Compared with the prior art, the new preparation method disclosed by the invention has the advantages that the used raw materials are cheap and easily available, technology can easily realize industrialization, and the obtained final product is high in purity; no danger technology is adopted, and equipment is simple; and route is novel, and synthesis route is short.
N-sulfamoyl-N'-benzopyranpiperidine compounds and uses thereof
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Page/Page column 7, (2008/06/13)
N-sulfamoyl-N′-benzopyranpiperidine compounds of formula I and their physiologically acceptable acid addition salts, pharmaceutical compositions comprising them, processes for their preparation, and their use for the treatment and/or inhibition of glaucoma, epilepsy, bipolar disorders, migraine, neuropathic pain, obesity, type II diabetes, metabolic syndrome, alcohol dependence, and/or cancer, and related concomitant and/or secondary diseases or conditions.