71015-20-8

Basic information

• Product Name: 2-Isocyano-2-methylpropanoic acid methyl ester
• Synonyms: 2-Isocyano-2-methylpropanoic acid methyl ester
• CAS NO: 71015-20-8
• Molecular Formula: C₆H₉NO₂
• Molecular Weight: 0
• Mol File: 71015-20-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Isocyano-2-methylpropanoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Isocyano-2-methylpropanoic acid methyl ester(71015-20-8)
• EPA Substance Registry System: 2-Isocyano-2-methylpropanoic acid methyl ester(71015-20-8)

Safety Data

• Hazardous Substances Data: 71015-20-8(Hazardous Substances Data)

Usage

InChI:InChI=1/C6H9NO2/c1-6(2,7-3)5(8)9-4/h1-2,4H3

Upstream product

• 60421-25-2 N-formyl-2-aminoisobutyric acid 
• 17746-46-2 α-nitrosoisobutyrate 
• 109862-23-9 Methyl-2-formamidoisobutyrate 

Downstream Products

• 284688-79-5 Z-Aib-2Dpy-Aib-OMe 
• 111698-34-1 (+/-)_S-isopropyl phenylsulfinate 

Relevant articles and documents

PHYTOSPHINGOSINE DERIVATIVES AS ADJUVANTS IN IMMUNE STIMULATION

The invention relates to phytosphingosine derivatives, suitable as adjuvants in immune stimulation. The invention further relates to pharmaceutical compositions comprising such compounds and the medical use of said compounds and/or compositions in therapeutic or prophylactic methods of immune stimulation in a subject, and for use in the treatment of a disease, for which stimulation of an immune response in a subject produces a therapeutic benefit. The invention further relates to the phytosphingosine derivative as described herein for use as an adjuvant in a method of vaccinating a subject. The invention further relates to the phytosphingosine derivative as described herein for use in stimulating antibody production, stimulating an immune response against infection, stimulating an immune response against a cancer, or preventing and/or treating septic shock. The invention further relates to a method for the manufacture of said derivatives comprising an Ugi-4-component reaction (Ugi-4CR).

Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates

A new method for the synthesis of secondary thiocarbamates from readily available isocyanides and thiosulfonates with broad functional group tolerance is reported. The reaction proceeds under mild reaction conditions in isopropanol and is catalyzed by inexpensive sodium iodide.

Ammonium chloride promoted three-component synthesis of 5-iminooxazoline and its subsequent transformation to macrocyclodepsipeptide

(Chemical Equation Presented) A three-component reaction of an α,α-disubstituted α-isocyanoacetamide, an aldehyde and an amino alcohol afforded the 5-iminooxazoline, which, upon saponification, cyclized under acidic conditions to provide the macrocyclodepsipeptide in good overall yield.