71022-81-6

Upstream product

• 68593-68-0 2-(2-formyl-1-pyrrolyl)-3-cyanothiophene 
• 98-86-2 acetophenone 
• 60-29-7 diethyl ether 

Relevant academic research and scientific papers

PYRROLOTHIENODIAZEPINES PART I: SYNTHESIS AND STUDY OF THE REACTION PATHWAY

Synthesis of 5,6-dihydro-4-oxo-4H-pyrrolothienodiazepines is achieved starting from 2-(2-formyl-1H-pyrrol-1-yl)-3-thiophenecarbonitrile.Reaction pathway is demonstrated via isolation of intermediates involved in the synthetic reaction.

Pyrrolo [1,2A] thieno [3,2-F] [1,4] diazepines

The invention relates to pyrrolo [1,2-a] thieno [3,2-f][1,4]diazepine compounds of the formula (I) STR1 in which: R1 is hydrogen; alkyl optionally substituted with alkoxy, hydroxy, cycloalkyl, or phenyl; or alkyl- or arylsulfonyl; R2 is hydrogen, phenyl, or phenylalkyl; alkyl optionally substituted with hydroxyl, alkoxy, oxo, cycloalkyl or phenyl; or optionally substituted amino; R3 represents hydrogen or alkyl, and R4 and R5 independently represent: hydrogen, alkyl optionally substituted with alkoxy, cycloalkyl, or phenyl; or phenyl; their isomers, diastereoisomers and enantiomers as well as their addition salts with pharmaceutically-acceptable acids. The compounds are useful for treating cerebral ischemia, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, and hyperglycemia and are obtained in a few steps from the corresponding substituted 2-(1-pyrrolyl)thiophenes STR2 Y=--CHO or H; X= CN, CONH2, CH2 NHCOR2, or CH2 NH2.