71025-26-8

Basic information

• Product Name: 4-methylthiobenzoylhydrazine
• Synonyms: 4-methylthiobenzoylhydrazine
• CAS NO: 71025-26-8
• Molecular Weight: 166.247
• Mol File: 71025-26-8.mol

Chemical Properties

• CAS DataBase Reference: 4-methylthiobenzoylhydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylthiobenzoylhydrazine(71025-26-8)
• EPA Substance Registry System: 4-methylthiobenzoylhydrazine(71025-26-8)

Safety Data

• Hazardous Substances Data: 71025-26-8(Hazardous Substances Data)

Upstream product

• 2168-80-1 4-methyldithioic acid 
• 57149-19-6 (4-methyl-thiobenzoylsulfanyl)-acetic acid 
• 50684-43-0 4-methylbenzothioic S-acid 
• 543-27-1 isobutyl chloroformate 
• 75-15-0 carbon disulfide 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 5977-87-7 4-methyl-dithiobenzoic acid methyl ester 

Downstream Products

• 17473-00-6 2-(4-chlorophenyl)-5-(p-tolyl)-1,3,4-thiadiazole 
• 17473-15-3 2-(4-methoxyphenyl)-5-(p-tolyl)-1,3,4-thiadiazole 
• 1366397-88-7 2-(p-tolyl)-1,3,4-thiadiazole 
• 26038-15-3 2-methyl-5-(p-tolyl)-1,3,4-thiadiazole 
• 16112-32-6 2-(4-methylphenyl)-5-phenyl-1,3,4-thiadiazole 

Relevant articles and documents

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2)

5′-Phenyl-3′H-spiro[indoline-3,2′-[1,3,4]thiadiazol]-2-one inhibitors of ADAMTS-5 (Aggrecanase-2) have been prepared via commercially available starting materials. Selected compounds 23, 33-35 show sub-micromolar ADAMTS-5 potency and strong SAR trends with selectivity over the related metalloproteases ADAMTS-4 (Aggrecanase-1), MMP12, and MMP13. This series of compounds represents progress toward a selective ADAMTS-5 inhibitor as a disease modifying osteoarthritis drug.

ANTIFUNGAL AGENTS

Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents, wherein: R1, R2 and R3 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (I), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.

Thiohydrazides and 1,3,4-Thiadiazoles by Hydrazinolysis of Dithiocarboxylic Esters

The reaction of 1,1-dithiooxalicesters 1 and heteroaryldithiocarboxylic esters 2 with excess hydrazine yields stable thiohydrazides 3 and 4, respectively.If the hydrazinolysis is carried out with only 0.5 equivalent hydrazine 1,3,4-thiadiazoles 6 and 7, e

Antibacterial 1-normon-2-yl-heterocyclic compounds

Compounds of formula (I): STR1 wherein STR2 is a 5-membered heterocyclic group having a 6-?electron system, the five ring atoms being either (a) one carbon atom and four atoms selected from carbon and nitrogen, (b) two carbon atoms, two nitrogen atoms and one atom selected from oxygen and sulphur, or (c) four carbon atoms and one atom selected from oxygen and sulphur and R1 is a substituent on a carbon or nitrogen of STR3 selected from C1-20 alkyl, C2-8 alkenyl aryl, aralkyl and heterocyclyl, each of which may optionally be substituted; hydrogen and C3-7 cycloalkyl, and, where appropriate, R2 is a substituent on a carbon or nitrogen of STR4 and when present is the same or different to R1 and is selected from C1-20 alkyl, C2-8 alkenyl, aryl, aralkyl and heterocyclyl each of which may optionally be substituted; hydrogen and C3-7 cycloalkyl, have antibacterial and antimycoplasmal activity.