71028-02-9

Basic information

• Product Name: cis-2-(4-methoxyphenyl)-4-methyl-5-phenyl-4,5-dihydrooxazole
• CAS NO: 71028-02-9
• Molecular Weight: 267.327
• Mol File: 71028-02-9.mol

Chemical Properties

• CAS DataBase Reference: cis-2-(4-methoxyphenyl)-4-methyl-5-phenyl-4,5-dihydrooxazole(CAS DataBase Reference)
• NIST Chemistry Reference: cis-2-(4-methoxyphenyl)-4-methyl-5-phenyl-4,5-dihydrooxazole(71028-02-9)
• EPA Substance Registry System: cis-2-(4-methoxyphenyl)-4-methyl-5-phenyl-4,5-dihydrooxazole(71028-02-9)

Safety Data

• Hazardous Substances Data: 71028-02-9(Hazardous Substances Data)

Upstream product

• 86117-77-3 4-methoxy-N-(1-phenylpropan-2-yl)benzamide 
• 71027-74-2 N-((1RS,2SR)-2-hydroxy-1-methyl-2-phenyl-ethyl)-4-methoxy-benzamide 
• 873-66-5 1-propenylbenzene 
• 100-07-2 4-methoxy-benzoyl chloride 

Relevant articles and documents

Direct asymmetric synthesis of oxazolines from olefins using a chiral nitridomanganese complex: A novel three-component coupling leading to chiral oxazolines

A new synthetic method for chiral oxazolines has been developed by N1 unit transfer to olefins using a chiral nitridomanganese complex. When trans-disubstituted styrenes were treated with chiral complex 1 in the presence of an acid chloride, oxazolines we

Visible light bromide catalysis for oxazoline, pyrrolidine, and dihydrooxazine synthesesviaCsp3-H functionalizations

A catalytic benzylic Csp3-H functionalization protocol is described here. This visible light-mediated process is centered on the utilization of a bromide catalyst and oxidant to generate a nitrogen (N)-centered radical for a site-selective hydrogen atom transfer (HAT) process. This strategy enabled the unconventional syntheses of a number of N-heterocycles dependent on the amide identity. We also discovered a nucleophilicity-dependent kinetic resolution for stereochemical differentiation of Csp3-H bonds that enabled the stereoselective synthesis ofcis- andtrans-oxazolines.

Asymmetric N1 unit transfer to olefins with a chiral nitridomanganese complex: Novel stereoselective pathways to aziridines or oxazolines

Chiral nitridomanganese complex 1 was found to be a highly potential N1 unit source for the asymmetric synthesis of aziridines and 2-oxazolines from olefins such as styrene and its derivatives. When sulfonyl chlorides were employed as activators of the complex in the presence of pyridine, pyridine N-oxide, and a silver salt, the reaction of olefins with complex 1 proceeded smoothly to afford the N-sulfonylated aziridines. The aziridination of styrene derivatives with complex 1 using 2-trimethylsilylethanesulfonyl chloride (SESC1) gave the N-SES-aziridines, which were easily converted into chiral N-unsubstituted aziridines. It was found that the reaction was applicable to the asymmetric synthesis of 2-oxazolines from olefins when acyl chlorides were employed as activators. Complex I provided an effective asymmetric environment for trans-disubstituted styrenes in the reaction (up to 92% ee). This is the first example of a direct asymmetric synthesis of 2-oxazolines from olefins. Additional experiments, conducted during the course of this investigation, suggest that the isomerization of the N-acylaziridine intermediate is involved in this reaction.

Isoquinoline Synthesis via 2-Oxazolines. Part VII. N-Styrylamides as Intermediates in the Pictet-Gams Reaction

Attempts have been described aiming at isolation of N-styrylamides in the course of Pictet-Gams reaction.Generation of the compounds as intermediates of the reaction has been demonstrated on grounds of hydroxyamide cyclization, using deuterated chlorophosphoric acid as a dehydrating agent.Key words: amino alcohols, isoquinoline, oxazoline