71030-36-9Relevant academic research and scientific papers
Repurposing Resveratrol and Fluconazole to Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism
El-Sherbeni, Ahmed A.,El-Kadi, Ayman O. S.
, p. 1278 - 1288 (2016/04/26)
Cytochrome P450 (P450) enzymes metabolize arachidonic acid (AA) to several biologically active epoxyeicosatrienoic acids (EETs) and hydroxyeicosatetraenoic acids (HETEs). Repurposing clinically-approved drugs could provide safe and readily available means
Controlled formation of mono- and dihydroxy-resolvins from EPA and DHA using soybean 15-lipoxygenase
Dobson, Eleanor P.,Barrow, Colin J.,Kralovec, Jaroslav A.,Adcock, Jacqui L.
, p. 1439 - 1447 (2013/06/26)
Resolvins and protectins are important anti-infl ammatory and pro-resolution compounds derived from the enzymatic oxidation of omega-3 fatty acids all -cis -5,8,11,14,17- eicosapentaenoic acid (EPA) and all -cis -4,7,10,13,16,19-docosahexaenoic acid (DHA). We have developed a simple, controlled method to synthesize an array of resolvin and protectin analogs from fatty acid starting materials using soybean 15-lipoxygenase. The conditions were optimized for the production of both mono- and dihydroxy derivatives, with enzyme concentration and pH found to have a signifi cant effect on the reaction products. The methods were applied to fi ve biologically important omega-3 and omega-6 fatty acid substrates. Mono- and dihydroxy compounds were successfully synthesized from all substrates and the products were characterized by normal phase (NP) HPLC , GC-MS, TOF-MS, UV-visible (UV-vis) spectroscopy, and NMR spectroscopy. The methods could be further applied to any polyunsaturated fatty acids containing the cis -1,4,7,10-undecatetraene moiety to produce a range of novel compounds with potential biological activity. Copyright
Synthesis of phospholipids bearing a conjugated oxo-polyunsaturated fatty acid residue
Zhu, Changjin,Ohashi, Takaaki,Morimoto, Tatsuya,Onyango, Arnold N.,Takao, Kaneko,Shimizu, Sakayu,Nakajima, Shuhei,Baba, Naomichi
, p. 500 - 501 (2007/10/03)
2-(15'-Oxo-5',8',11',13'-eicosatetraenoyl)-1-stearoyl- sn- glycerol(3)phosphocholine (APC-CO) 1 and 2 and 2-(13'-oxo-9',11'- octadecadienoyl)-1-stearoyl-sn-glycero(3)phosphocholine (LPC-CO) 3 are synthesized and an analytical system established for the determination of geometrical isomers at the 13' position of APC-CO.
ISOMERIZATION OF EPOXIDES TO ALLYLIC ALCOHOLS USING METHYLMAGNESIUM N-CYCLOHEXYLISOPROPYLAMIDE
Mosset, Paul,Manna, Sukumar,Viala, Jacques,Falck, J.R.
, p. 299 - 302 (2007/10/02)
The scope of methylmagnesium N-cyclohexylisopropylamide promoted isomerizations of epoxides to allylic alcohols is described.
