710351-85-2Relevant academic research and scientific papers
Design, synthesis and antitumor study of a series of N-Cyclic sulfamoylaminoethyl substituted 1,2,5-oxadiazol-3-amines as new indoleamine 2, 3-dioxygenase 1 (IDO1) inhibitors
Chen, Shulun,Guo, Wei,Liu, Xiaohua,Sun, Pu,Wang, Yi,Ding, Chunyong,Meng, Linghua,Zhang, Ao
, p. 38 - 55 (2019/06/25)
Indoleamine 2, 3-dioxygenase 1 (IDO1) plays a key role in tryptophan catabolism which is an important mechanism in immune tolerance. The small molecule epacadostat is the most advanced IDO1 inhibitor, but its phase III trials as a single agent or in combi
Substituted benzazoles and methods of their use as inhibitors of Raf kinase
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Page 387, (2008/06/13)
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
