71037-71-3

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-6-(1H-imidazol-1-yl)pyridazine is used as a key intermediate in the synthesis of new drugs. Its chemical structure and properties make it a promising candidate for the development of pharmaceuticals with potential therapeutic applications in treating various diseases and disorders.
Used in Agrochemical Industry:
3-Chloro-6-(1H-imidazol-1-yl)pyridazine is used as a precursor in the development of agrochemicals. Its potential as an antifungal and antibacterial agent makes it a valuable component in the creation of new agricultural products designed to protect crops and enhance yield.
Used in Antifungal and Antibacterial Applications:
3-Chloro-6-(1H-imidazol-1-yl)pyridazine is used as an active ingredient in antifungal and antibacterial formulations. Its potential to inhibit the growth of fungi and bacteria makes it a useful compound in the development of treatments for various infections and diseases.
Used in Disease and Disorder Treatment:
3-Chloro-6-(1H-imidazol-1-yl)pyridazine has been investigated for its potential use in the treatment of various diseases and disorders. Its unique chemical structure and properties may contribute to the development of new therapeutic agents with improved efficacy and safety profiles.

InChI:InChI=1/C7H5ClN4/c8-6-1-2-7(11-10-6)12-4-3-9-5-12/h1-5H

Upstream product

• 288-32-4 1H-imidazole 
• 141-30-0 3,6-dichlorpyridazine 
• 122-78-1 phenylacetaldehyde 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 623581-31-7 C₁₉H₂₁N₅O 
• 100240-25-3 3-(3,5-dimethylphenoxy)-6-(1 H-imidazol-1-yl)pyridazine 
• 1417455-20-9 3-(1H-imidazol-1-yl)-6-(3-methylphenyl)pyridazine 
• 110696-70-3 2-{2-[Benzyl-(2-phenoxy-ethyl)-amino]-ethyl}-6-imidazol-1-yl-2H-pyridazin-3-one 
• 110696-51-0 6-Imidazol-1-yl-2-[2-(2-phenoxy-ethylamino)-ethyl]-2H-pyridazin-3-one 
• 138803-61-9 1-(6-Imidazol-1-yl-pyridazin-3-yloxy)-3-[2-(2-methoxy-phenoxy)-ethylamino]-propan-2-ol 
• 138803-60-8 1-(6-Imidazol-1-yl-pyridazin-3-yloxy)-3-(2-phenoxy-ethylamino)-propan-2-ol 

Relevant academic research and scientific papers

Selective mono-amination of dichlorodiazines

A mild, easy-to-perform, and versatile method for the formation of aminochlorodiazines from reaction of several types of dichlorodiazines (i.e., pyridazines, pyrimidines, and pyrazines) with primary or secondary amines in ethanol in the presence of trieth

Synthesis, antibacterial and antioxidant properties of pyrazolylpyridazines

A number of 6-chloro-3-(pyrazol-1′-yl) pyridazines were prepared from 3,6-dichloropyridazine via either reaction with hydrazine followed I by reaction with appropriate reagents to develop the pyrazole or through a nucleophilic reaction with a pyrazole. So

An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines

3-Amino-6-aryl- and 3-amino-6-heteroarylpyridazines have been obtained in generally good yield using a nickel-catalyzed electrochemical cross-coupling between 3-amino-6-chloropyridazines and aryl or heteroaryl halides at room temperature. Comparative experiments involving classical palladium-catalyzed reactions, such as Suzuki, Stille, or Negishi cross-couplings, reveal that the electrochemical method can constitute a reliable alternative tool for biaryl formation. A possible reaction mechanism is proposed on the basis of electrochemical analyses.

Substituted diazabicycloalkane derivatives

Compounds of formula (I) [in-line-formulae]Z-Ar1—Ar2??(I) [/in-line-formulae] wherein Z is a diazabicyclic amine, Ar1 is a 5- or 6-membered aromatic ring, and Ar2 is selected from the group consisting of an unsubstituted or substituted 5- or 6-membered heteroaryl ring; unsubstituted or substituted bicyclic heteroaryl ring; 3,4-(methylenedioxy)phenyl; carbazolyl; tetrahydrocarbazolyl; naphthyl; and phenyl; wherein the phenyl is substituted with 0, 1, 2, or 3 substituents in the meta- or para-positions. The compounds are useful in treating conditions or disorders prevented by or ameliorated by α7 nAChR ligands. Also disclosed are pharmaceutical compositions comprising compounds of formula (I) and methods for using such compounds and compositions.

Anti-virally active pyridazinamines

Anti-virally active pyridazinamines, compositions containing the same and methods of treating viral diseases in warm-blooded animals.

Synthesis and antihypertensive activity of new 6-heteroaryl-3-hydrazinopyridazine derivatives

The synthesis and pharmacological activity of new 6-heteroaryl-3-hydrazinopyridazines with antihypertensive action are described. The introduction of pyrrole, pyrazole, imidazole, triazole, tetrazole, thiophene, indole, and carbazole heterocyclic rings into the 6 position of the pyridazine nucleus has been carried out by three different methods of synthesis. The hypotensive action has been examined on normotensive and spontaneously hypertensive rats by comparison with dihydralazine (I). 6-Imidazol-1-yl derivatives have proved particularly active. Of these derivatives 3-hydrazino-6-(2-methylimidazol-1-yl)pyridazine (7c) achieves 4.9 times the activity of dihydralazine when administered orally to spontaneously hypertensive rats. The LD50 values of 7c and dihydralazine are very similar.