71046-35-0Relevant academic research and scientific papers
Total Synthesis of Aaptamine, Demethyloxyaaptamine, and Their 3-Alkylamino Derivatives
Gao, Yuan,Yang, Fan,Sun, Fan,Liu, Lei,Liu, Bo,Wang, Shu-Ping,Cheng, Chun-Wei,Liao, Hongze,Lin, Hou-Wen
, p. 1430 - 1433 (2019)
A simple and efficient synthetic route for preparing the benzonaphthyridine framework is reported. Only seven steps are needed for the assembly of 3-alkylamino aaptamine from inexpensive isoquinoline 6 by this route with about 20% overall yield. The two k
A SYNTHESIS OF AAPTAMINE FROM 6,7-DIMETHOXY-1-METHYLISOQUINOLINE
Batczewski, Piotr,Mallon, M. Kieran J.,Street, Jonathan D.,Joule, John A.
, p. 3193 - 3198 (2007/10/02)
6,7-Methoxy-1-methylisoquinoline 3a was nitratwd at C-8, oxidised to thenitro aldehyde 3r and then condensed with nitromethane using alumina as base to give the alcohol 3s, dehydration of which produced the nitroethene 3t.Iron-acetic acid treatment of com
Oxydation vanadique de la papaverine en milieu sulfurique 2,5 M et 5 M
Postaire, E.,Martinez, D.,Viel, C.,Chastagnier, M.,Hamon, M.
, p. 982 - 988 (2007/10/02)
Vanadic oxidation of papaverine 1 in 5 M sulfuric acid media shows a full oxidation into carbon dioxide and water.However, according to the experimental conditions, and in 2.5 M and 5 M sulfuric acid media, intermediates and products have been identified: papaveraldine 2, hemipinimide 4, meta-hemipinic acid 3, 6,7-dimethoxy isoquinoline 5, 1-formyl 6,7-dimethoxy isoquinoline 6, 1-acetyl 6,7-dimethoxy isoquinoline 7, 4-hydroxy 6-demethyl papaveraldine 8, 4-hydroxy 4'demethyl papaveraldine 9, 3-hydroxy 6-demethyl papaveraldine 10 and 3-hydroxy 4'-demethyl papaveraldine 11.
Isoquinoline propionamides exhibiting analgesic properties
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, (2008/06/13)
Disclosed are novel isoquinoline propionamides and their acid salts represented by the structural formula: STR1 wherein R is alkyl of 1 to 6 carbon atoms, methylcycloalkyl of 4 to 7 carbon atoms or alkaryl of 7 to 8 carbon atoms; R' is H or OCH3/sub
